Imaging and Histopathologic Correlation of PediatricOculo- Orbital Tumors Evaluated in a Tertiary Level Teaching Hospital in Ethiopia: Three Years Retrospective Study
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Date
2020-12
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Addis Abeba University
Abstract
Objective: This study is conducted to assess the cross sectional (CT and MRI) imaging
pattern of pediatricoculo-orbital tumors and correlate with histopathologic finding and there
is also general discussion on sociodemographic characteristics and clinical profileof these
patients. Retinoblastoma is discussed in further detail.
Method: In a retrospective cross sectional studyconducted in a period of 3 years from
February 2017 to January 2020 G.C, The medical records of all pediatric patients with orbital
tumors evaluated at TASH oncology unit were reviewed.All Patients with initial pretreatment
cross sectional imaging study and histopathologic analysis and patients who were
conservatively treated for retinoblastoma with diagnosis established through evaluation under
general anesthesiawere included in the study.
DatawascollectedusingapreparedchecklistandenteredusingMicrosoftexcelsoftwareandlatertran
sferredtoSPSSversion 20 foranalysis.
Result:Malignant tumors represented 96.1% of the total 101 cases in our series. The most
common origin of orbital tumor was secondaryextension(69.6%) followed by primary orbital
tumors 11(16.6%) and metastasis 9(13.6%).The most common primary oculo-orbital tumor
was retinoblastoma followed by RMS and optic glioma. Neuroblastoma and leukemiawere
the most common origins of orbital metastasis. The patients commonly presented
withproptosis(78%)followed by leukocorea(16%). There was correlation between imaging
and histologic finding in 89.7% of the oculo-orbital tumors in our study. The highest
concordance rate was seen for retinoblastoma and optic glioma. The most common orbital
subspace involved was the intraconal site. Patients with retinoblastoma commonly presented
at an advanced stage with orbital and intracranial extension.
Conclusion: Pediatric orbital tumors are diagnosed at an advanced stage in our setup with
grave complications which can be attributed to the late presentation from the parents’ side
and late referral from the primary care physicians. Thus, it is utmost importance to create
awareness within the health care workers and the society at large for early detection with can
salvage the vision and the life of this patients. Imaging plays an important role in the
diagnosis and management of patients with oculo-orbital tumor. Communication between
radiologist, pathologist and treating ophthalmologist is important in reaching the final
diagnosis and for a better outcome in these patients.
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Keywords
PediatricOculo-Orbital Tumors,Imaging