Imaging and Histopathologic Correlation of PediatricOculo- Orbital Tumors Evaluated in a Tertiary Level Teaching Hospital in Ethiopia: Three Years Retrospective Study

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Addis Abeba University


Objective: This study is conducted to assess the cross sectional (CT and MRI) imaging pattern of pediatricoculo-orbital tumors and correlate with histopathologic finding and there is also general discussion on sociodemographic characteristics and clinical profileof these patients. Retinoblastoma is discussed in further detail. Method: In a retrospective cross sectional studyconducted in a period of 3 years from February 2017 to January 2020 G.C, The medical records of all pediatric patients with orbital tumors evaluated at TASH oncology unit were reviewed.All Patients with initial pretreatment cross sectional imaging study and histopathologic analysis and patients who were conservatively treated for retinoblastoma with diagnosis established through evaluation under general anesthesiawere included in the study. DatawascollectedusingapreparedchecklistandenteredusingMicrosoftexcelsoftwareandlatertran sferredtoSPSSversion 20 foranalysis. Result:Malignant tumors represented 96.1% of the total 101 cases in our series. The most common origin of orbital tumor was secondaryextension(69.6%) followed by primary orbital tumors 11(16.6%) and metastasis 9(13.6%).The most common primary oculo-orbital tumor was retinoblastoma followed by RMS and optic glioma. Neuroblastoma and leukemiawere the most common origins of orbital metastasis. The patients commonly presented withproptosis(78%)followed by leukocorea(16%). There was correlation between imaging and histologic finding in 89.7% of the oculo-orbital tumors in our study. The highest concordance rate was seen for retinoblastoma and optic glioma. The most common orbital subspace involved was the intraconal site. Patients with retinoblastoma commonly presented at an advanced stage with orbital and intracranial extension. Conclusion: Pediatric orbital tumors are diagnosed at an advanced stage in our setup with grave complications which can be attributed to the late presentation from the parents’ side and late referral from the primary care physicians. Thus, it is utmost importance to create awareness within the health care workers and the society at large for early detection with can salvage the vision and the life of this patients. Imaging plays an important role in the diagnosis and management of patients with oculo-orbital tumor. Communication between radiologist, pathologist and treating ophthalmologist is important in reaching the final diagnosis and for a better outcome in these patients.



PediatricOculo-Orbital Tumors,Imaging