Assessment of glycemic control among Type 2 Diabetes Mellitus patients on metformin treatment in Wolaita Sodo University Teaching Referral Hospital, SNNPR, Ethiopia.
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Date
2021-01
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Addis Abeba University
Abstract
Background: Diabetes mellitus is a group of metabolic diseases characterized by hyperglycemia
resulting from defects in insulin secretion, insulin action, or both. The chronic hyperglycemia of diabetes
is associated with long-term damage, dysfunction, and failure of various organs, especially the eyes,
kidneys, nerves, heart, and blood vessels. Glycemic control is considered as the principle helpful
objective for counteraction of organ harm and different intricacies of diabetes. The first line of remedy for
T2DM is metformin, which lack relative facet outcomes and its brilliant affected person tolerance.
Objective: To assess glycemic control among Type 2 Diabetes Mellitus patients on metformin treatment
in Wolaita Sodo University Teaching Referral Hospital, SNNPR, Ethiopia.
Methods: A Hospital based Cross sectional study design was carried out among diabetic adults from
February 2021 to April 2021 at Wolaita Sodo Hospital, Southern Ethiopia. A total of 140 study
participants were selected during follow up by consecutive sampling technique. Structured questionnaires
were used for socio-demographic, and anthropometric data collection. In addition, after overnight (8-12
hours) fasting 5 ml of blood sample was collected from each participant by serum separator, (SS)tube,
and Fasting blood sugar (FBS), HbA1c and lipid profiles were measured. Data were analyzed by using
Epi data version 3.1 and SPSS version 21.0 statistical software. Descriptive statistics (Frequencies, mean,
SD, percentage)were used to explain study population in relation to relevant variables. Logistic
regression was used for data comparison, P value <0.05 were accepted as statistically significant, and
finally the result was presented using text, tables, charts and graphs.
Result: The age of study participants ranged from 25-80 years with an overall mean ± SD age of
48.4±10.6 years. Of the total 134 patients, 58% (78)had a mean HbA1c 7.9% resulting in poor glycemic
control. We identified that patients with age range between 41-55 years (p=0.005) were poorly managed
their blood glucose level compared to the other age groups under study. Poor glycemic control were
associated with age (AOR:8.87, 95% CI 1.9-40),Triglyceride (AOR:0.27, 95% CI 0.08-0.89), metformin
taking (AOR: 0.005,95%CI 0.00-0.04) and comorbidity (AOR: 0.21, 95%CI 0.05-1.2).
Conclusion: This study shows nearly two-third (58.2%) of diabetic patients attending Wolaita Sodo
Hospital ,Southern Ethiopia had poor glycemic control. The variables found to influence the outcome of
glycemic control in the present study were age, comorbidity, Triglyceride and dose of metformin taking.
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Keywords
Diabetes Mellitus, Glycemic Control, Glycated Hemoglobin