Assessment of Glycemic Control among Type 2 Diabetes Mellitus Patients on Metformin Treatment in Wolaita Sodo University Teaching Referral Hospital, SNNPR, Ethiopia.
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Date
2021-01
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Addis Abeba University
Abstract
Background: Diabetes mellitus is a group of metabolic diseases characterized by hyperglycemiaresulting from defects in insulin secretion, insulin action, or both. The chronic hyperglycemia of diabetesis associated with long-term damage, dysfunction, and failure of various organs, especially the eyes,kidneys, nerves, heart, and blood vessels. Glycemic control is considered as the principle helpfulobjective for counteraction of organ harm and different intricacies of diabetes. The first line of remedy forT2DM is metformin, which lack relative facet outcomes and its brilliant affected person tolerance.
Objective: To assess glycemic control among Type 2 Diabetes Mellitus patients on metformin treatmentin Wolaita Sodo University Teaching Referral Hospital, SNNPR, Ethiopia.
Methods: A Hospital based Cross sectional study design was carried out among diabetic adults fromFebruary 2021 to April 2021 at Wolaita Sodo Hospital, Southern Ethiopia. A total of 140 studyparticipants were selected during follow up by consecutive sampling technique. Structured questionnaires were used for socio-demographic, and anthropometric data collection. In addition, after overnight (8-12hours) fasting 5 ml of blood sample was collected from each participant by serum separator, (SS)tube,and Fasting blood sugar (FBS), HbA1c and lipid profiles were measured. Data were analyzed by usingEpi data version 3.1 and SPSS version 21.0 statistical software. Descriptive statistics (Frequencies, mean,SD, percentage)were used to explain study population in relation to relevant variables. Logisticregression was used for data comparison, P value <0.05 were accepted as statistically significant, andfinally the result was presented using text, tables, charts and graphs.
Result: The age of study participants ranged from 25-80 years with an overall mean ± SD age of48.4±10.6 years. Of the total 134 patients, 58% (78)had a mean HbA1c 7.9% resulting in poor glycemiccontrol. We identified that patients with age range between 41-55 years (p=0.005) were poorly managedtheir blood glucose level compared to the other age groups under study. Poor glycemic control wereassociated with age (AOR:8.87, 95% CI 1.9-40),Triglyceride (AOR:0.27, 95% CI 0.08-0.89), metformintaking (AOR: 0.005,95%CI 0.00-0.04) and comorbidity (AOR: 0.21, 95%CI 0.05-1.2).
Conclusion: This study shows nearly two-third (58.2%) of diabetic patients attending Wolaita Sodo Hospital ,Southern Ethiopia had poor glycemic control. The variables found to influence the outcome ofglycemic control in the present study were age, comorbidity, Triglyceride and dose of metformin taking.
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Keywords
Diabetes Mellitus, Glycemic Control, Glycated Hemoglobin