Application of Cox Proportional Hazards Model in Case of Tuberculosis Patients in Selected Addis Ababa Health Centers, Ethiopia
No Thumbnail Available
Date
2013-06
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Addis Ababa University
Abstract
Tuberculosis (TB) is a chronic infectious disease and mainly caused by mycobacterium
tuberculosis (MTB). It has been one of the major causes of mortality in Ethiopia. The
objective of the study was to identify factors that affecting the survi val of the patients
with tuberculosis who started treatment for tu berculosis. This was a retrospective study in
six randomly se lected health centers in Addis Ababa, Ethiopi a. The data were obtained
from med ical records ofTB pat ients regi stered from September 2012 to August 20 13 and
treated under DOTS strategy. Out of the total 826 registered TB patients 105 ( 12.7 1%)
di ed during the study period and 7 12(87.29%) were censored . Based on Kaplan Meier
survival curves, log rank lest and Wi lcoxon tcst it was found that the patients had
statistically significant d ifferences in survival experience with respect to age, body
weight at initiation of treatment, TB patient category and HIV status. Multivariable Cox
hazards regression anal ysis revea led that the covariates age, TB patient category, HIV
and age by HIV interaction were significant risk factors associated with death status in
TB patients.
Description
Keywords
Application of Cox Proportional Hazards Model In case