Comparison of the effects of intravenous lidocaine and propofol administration on attenuation of hemodynamic response during extubation in adult elective surgical patient at Asella teaching and referral hospital in 2019/20.(Prospective cohort study design)
| dc.contributor.advisor | Aregawi, Adugna(Bsc,Msc, ass. Professor of Anesthesia ) | |
| dc.contributor.advisor | Abrar, Meron(MSc in anesthesia) | |
| dc.contributor.author | Nigussie, Ephrem | |
| dc.date.accessioned | 2020-11-22T07:24:15Z | |
| dc.date.accessioned | 2023-11-05T09:39:52Z | |
| dc.date.available | 2020-11-22T07:24:15Z | |
| dc.date.available | 2023-11-05T09:39:52Z | |
| dc.date.issued | 2020-05 | |
| dc.description.abstract | Background: Tracheal extubation is the process of removing a tube from the trachea which is associated with an increased in heart rate, blood pressure, intracranial and intraocular pressure, coughing, bronchospasm and increased bleeding. Many techniques as well as drugs have been proposed for attenuation of airway and cardiovascular responses. Propofol and lidocaine are widely available drugs in resource limited setting though their relative effectiveness for smooth extubation is not well established. Objectives:To compare the effectiveness of intravenous lidocaine and propofolon attenuation of extubation induced hemodynamic responses in adult elective surgical patient from Nov 1,2019 – Feb 2020 at Asella teaching and referral hospital, Ethiopia. Methods: A prospective cohort study design was conducted on 72 eligible patients at Asella teaching and referral hospital from Nov 1/2019-Feb 30/2020. The study participant were allocated into three group; Group P(n=24)received 0.5 mg/kg propofol, group L(n=24)received 1.5 mg/kg lidocaine two minute prior to extubation and group C(n=24) were control groups. Data was collected using adopted and prepared questionnaires byobservation and chart review methods. Data was entered in to SPSS version 20 computer software and analyzed using one way ANOVA. Normality of the data was checked by Shapiro wilktest andTukeypost hoc test was used to compare difference between groups.p-value of <0.05 was considered as statistically significant. Results: After extubationheart rate, systolic, diastolic and mean arterial pressure decreased significantly in propofol and lidocaine groups than control group up to 10 minute. Heart rate, diastolic and mean arterial pressure was lower in group of propofol up to 5 minute and systolic blood pressure up to 3 minutes post extubation.Heart rate, diastolic and mean arterial pressure was lower in group of lidocaine after 5 minute and systolic blood pressure after 3 minutes post extubation.(p=0.001) Conclusions and recommendations:The administration of 0.5 mg/kg propofol or 1.5mg/kg lidocaine might help for attenuating extubation induced hemodynamic responses. We recommend anesthetist to use 0.5 mg/kg propofol or 1.5mg/kglidocaine for attenuating extubation induced hemodynamic response. | en_US |
| dc.identifier.uri | http://etd.aau.edu.et/handle/123456789/23438 | |
| dc.language.iso | en_US | en_US |
| dc.publisher | Addis Abeba University | en_US |
| dc.subject | Propofol, Lidocaine, Extubation, hemodynamic responses | en_US |
| dc.title | Comparison of the effects of intravenous lidocaine and propofol administration on attenuation of hemodynamic response during extubation in adult elective surgical patient at Asella teaching and referral hospital in 2019/20.(Prospective cohort study design) | en_US |
| dc.type | Thesis | en_US |