Characterization of Connective Tissue Disease Related Interstitial Lung Disease At Selcted Centers in Addis Abeba, Ethiopia: A 4 years retrospective study
| dc.contributor.advisor | Abdissa,Becky(MD, Ass.Prof.) | |
| dc.contributor.author | Zewdu,Ameha | |
| dc.date.accessioned | 2025-08-12T20:05:52Z | |
| dc.date.available | 2025-08-12T20:05:52Z | |
| dc.date.issued | 2024-02 | |
| dc.description.abstract | Background: CTD-ILD in one of the most frequent systemic manifestation of CTD which is responsible the majority of mortality and morbidity in these group of patient. Indeed characterization of connective tissue diseases related Interstitial lung diseases(CTD-ILD) includes clinical presentation, serological fiding ,Pulmonary function test(PFT) & high- resolution computed tomography (HRCT) findings will help in designing and implementing prevention and management interventions, thereby reducing the severity of illness and the number of deaths that could be associated with the disease. However published evidence are not much available in sub-saharan country including Ethiopia. Objective: To conduct a comprehensive characterization of CTD-related ILD including epidemiology, clinical presentation, radiological finding, PFT, and serological finding who attend the Rheumatology clinic at TASH, Lancet specialized hospital and Rheum specialty clinic from Jan 2020 – Feb 2024 Methods: A Multicenter cross-sectional analytical study was conducted by at the rheumatology clinic at TASH, Lancet and Rheum clinic in Addis Ababa, Ethiopia, during the period Jan 1st 2020 - Feb 2024. Data was collected using a structured checklist, and then entered and analyzed using SPSS version 26. Descriptive analysis was employed to identify the management gaps. Tables and figures were used to present the results. Result With a total patient 92 the majority of the patients are female(89.2) and male (10.8%) with a female to male ratio of 1:8 and the mmedianage of onset is 47.33 years. The most common CTD identified are RA (44.6%), SSC (40.9%) , PM/DM (6.5%), MCTD (4.3%), SLE (3.3%) & USCTD (1.1%). The most common clinical presentation is Cough (72.8%), Decreased exercise tolerance (40.5%) and Dyspnea (41.3% ) but 7.6% of the patient are asympromatic . The most identified Common Antibody Found In ILD are are ANA(47.8%), RF (47.8%) , Anti-scl-70 (37.0%) ,ACPA (29.7%) and frequently encountered ANA pattern are speckled (16.3 %), Homogenous (15.2 %) and nuclear (10.9%). The most frequqnt CXR finding is reticilonodular and GGO but 11% of the patient are normal .The most frequent identified HRCT pattern are NSIP (69.6%) and UIP (28.3%). PFT test done for only 7 patients and 4 patients have restrictive pattern and 3 patients have obstructive pattern. Conlussion Our study identified that CTD-ILD are more common in female and patient with RA % SSc. Most RA patient are older and usually have long duration of illness before the diagnosis of ILD. Relatively SSc patient are younger and most of them have Anti-scl-70 and speckled ANA pattern. We do not identified MTX associated pneumonitis. | |
| dc.identifier.uri | https://etd.aau.edu.et/handle/123456789/6509 | |
| dc.language.iso | en_US | |
| dc.publisher | Addis Ababa University | |
| dc.subject | CTD Connective Tissue Disease ILD – Interestial Lung Disease | |
| dc.title | Characterization of Connective Tissue Disease Related Interstitial Lung Disease At Selcted Centers in Addis Abeba, Ethiopia: A 4 years retrospective study | |
| dc.type | Thesis |