Establishment of Community Based Hematological Reference Intervals among Apparently Healthy Adults (18-60 years) in Mekelle, Tigrai, Northern Ethiopia from December 2018-May 2019: a Cross Sectional Study
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Date
2019-06
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Addis Abeba University
Abstract
Background: the medical laboratory service is a key component of the overall health system. The service provides useful laboratory data to prevent, control, treat and follow up for patients.Locally derived reference interval (RI) is recommended to interpret laboratory data because thereare various physiological and environmental factors which affect it. There was no referenceinterval established for hematological parameters in Mekelle, Tigrai, Northern Ethiopia.
Objective: Establishment of community based hematological reference intervals among apparently healthy adults (18-60 years) in Mekelle, Tigrai, Northern Ethiopia from December2018-May 2019: a cross sectional study.
Method: a cross-sectional study was employed in 344 apparently healthy adult (18-60)individuals who live at least 5 years in Mekelle city, Tigrai, northern Ethiopia from December2018-2019. About 4ml whole blood, stool and urine samples were collected. Hematologicalparameters were analyzed by Sysmex Kx-21 at Wukro hospital. Peripheral blood morphologyand malarial also were screened. The urine analysis, stool wet mount and Kato Katz wereexamined at collection sites and the formol-ether concentration was examined at the Tigrai health research institute. Data were entered and analyzed using SPSS version 20. The 2.5 and97.5th percentiles were calculated using non-parametric methods to determine 95% RI.
Result: The established reference interval for hematological parameters were White blood cell:3-10x109/L; lymphocyte percentage :19.6-57.6%; neutrophil percentage :24.91-70.3% for bothsexes (p>0.005); Red blood cell parameters were (p<0.001): 4.25-5.46 versus 4.7 -6.09 x 10/L,hemoglobin :12.4-15.5 versus 13.9-17.85 g/dl; hematocrit: 38-48 versus 41.6-53.2 % for malesand females respectively, but platelet was higher in females than males 158.3 -399.5 versus 142345.1x109 /L.
Conclusion: The established hematological reference interval for Mekelle city was differentfrom other reported studies. So, this finding is important to diagnosis, treatment and follows upof the clients of the Mekelle, Tigrai, Northern Ethiopia. There was statistically significantdifference based on gender difference on red blood cell, hemoglobin, hematocrit, platelet and mixed percentage.
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Apparently healthy adults, CBC, Hematology, Reference interval, Ethiopia