Assessment on Maginitude and Associated Factors on Suxamethoneum Induced Post Operative Myalgia in Adult Elective Surgical Patients From January 1, 2017 To March 1, 2017 At Zewuditu Memorial Hospital, Addis Ababa. Cross Sectional Study
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Date
2017-06
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Addis Abeba University
Abstract
Background: - Suxamethoneum is a depolarizing muscle relaxant first introduce into clinical
practice in 1951, it remains the drug of choice in clinical situations in which rapid paralysis and
air way control are priorities. The administrations of succinylcholine may produce post-operative
myalgia. Post-operative myalgia is thought to be caused by motor units firing at physiological
higher rate following Suxamethoneum administration, leading to unsynchronized muscle
contractions causing shearing forces of skeletal muscle fibers. The postoperative myalgia is
generalized aches and pains that commonly occur 24 to 48 hours after Suxamethoneum
Objectives: - To assess the magnitude and associated factors of Suxamethoneum induced post-
operative myalgia in adult elective surgical procedures that were under gone from January 1,
2017 to March 1, 2017 in Zewuditu memorial hospital, Addis Ababa, Ethiopia.
Method:-On 283 eligible patients Hospital based cross sectional study was conducted from
January 1, 2017 to March 1, 2017 G.C at Zewuditu Memorial Hospital, using structured
questionnaires and checklists and data were collected from all elective surgical patients who
fulfill the inclusion criteria during study period and the magnitude of post-operative myalgia was
calculated (%), associated factors with myalgia was investigated. Multivariate logistic regression
analysis was conducted to identify significant predictors based on p-value less than 0.05 with
95% confidence level.
Results:-Among 160 elective surgical patient the magnitude of Suxamethoneum induced post
operative myalgia in the first 24 to 48hours were in 92(57.5%) and in which at 24hour the
magnitude were about 84(52.5%) where as at 48 hour 74(46.2). The independent predictors of
Suxamethoneum induced post operative myalgia in this study are being female, incidence
fasciculation during induction and analgesia preoperatively.
Conclusion and recommendation:-The magnitude of Suxamethoneum induced post
operative myalgia in the first 24-48hrs was higher. To minimize the magnitude of
Suxamethoneum induced post operative myalgia and post operative patient discomfort different
prevention techniques should be applied. If possible it better to avoid the use of Suxamethoneum
regularly for elective surgical patients.
It is also recommended that premedication of patients with analgesic agent before induction
anesthesia and defaciculat with NDNMBA.
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Adult Elective Surgical Patients