Voltammetric study of paracetamole using glassy carbon electrode
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Date
2007-07
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Addis Ababa Universty
Abstract
This paper describes the use of electro analytical techniques, cyclic voltammetry (CV), square
wave voltammetry (SWV), and differential pulse voltammetry (DPV) in the study of the
electrochemical behavior of paracetamol in aqueous media and at the glassy carbon electrode.
The electrochemical reaction was found to be irreversible, involving the transfer of two
electrons. Aqueous phosphate buffer pH 7 was used as solvent and supporting electrolyte. An
optimization of instrumental parameters was performed for the differential pulse and square
wave voltammetric techniques. Differential pulse amplitude, pulse repeat time, and scan rate
chosen for differential pulse voltammetry were 30 mV, 0.5 sec, and 5 mv/s respectively.
Similarly for square wave voltammetry, the amplitude, frequency, and step potential chosen
were 25 mV, 25 Hz, and 5 mV respectively. Finally the interference study of tablet was studied
at aqueous phosphate buffer of pH 7.0.
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Keywords
carbon electrode