Profiling of Bacterial and Fungal Uropathogens, Antimicrobial Susceptibility Pattern of Bacterial Isolates, and Associated Risk factors among Pediatric Patients at St Paul Hospital Millennium Medical College.

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Addis Abeba University


Background: Urinary tract infection is an infection caused by uropathogens including bacteria and fungi .Which are the major cause of mortality and morbidity in pediatric patients. Early diagnosis and appropriate treatment is very mandatory. Increasing antimicrobial resistance (AMR) is also becoming a major challenge in the management of pediatric UTI cases.. This study is aimed in profiling of bacterial and fungal uropathogens and antimicrobial susceptibility pattern of bacterial isolates among pediatric UTI patients in SPHMMC. Methods: A hospital based cross-sectional study was conducted from January 2020-July 2020 among 227 UTI symptomatic pediatric patients. Clean –voided midstream urine was collected and analyzed according to standard microbiological procedures. Pathogenic isolates were identified by gram stain and different biochemical tests. Anti microbial susceptibility test was done by using Kirby - Bauer disk diffusion test following standard procedures. Data was analyzed by SPSS version 23. Result was interpreted by using simple and multivariate logistic regression at 95% confidence interval. P values <0.05 were considered as statistically significant. Result: The overall prevalence of UTI was 28.63 %( n=65). Gram negative bacteria were the predominant isolates of which E.coli was the most prevalently identified(n= 21; 32.32%) followed by klebsella pneumonia (n=17; 26.15%). Among the total 16 fungal isolates C.albicans(n=6; 9.23%) was the most prevalently identified. All gram negative bacteria showed100% resistance to ampicillin. MDR was seen among 27(55.1%) bacterial isolates. History of catheterization, Admission period, Positive leukocyte esterase and Nitrite had a significant association with UTI (P=<0.05) Conclusion: The study showed high prevalence of uropathogen and anti microbial resistance pattern(AMR) as compared to recent related studies in Ethiopia. Continuous and sustainable monitoring of antibiotics administration and conducting further studies on AMR and MDR is needed.



Symptomatic, Urinary tract infection, Multi drug resistance (MDR)