Prospective Cross sectional study of Radio-Pathologic correlation of soft tissue tumors in patients evaluated at Tikur Anbessa specialized hospital and St Paul millennium medical college, Addis Ababa University, Addis Ababa, Ethiopia, 2019
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Date
2019-08
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Addis Abeba University
Abstract
Introduction: Soft tissue is the supportive tissue of various organs and the non-epithelial, extra
skeletal structures exclusive of lympho-hematopoietic tissues. It includes fibrous connective
tissue, adipose tissue, skeletal muscle, blood/lymph vessels, and the peripheral nervous system.
Most soft tissue tumors are classified as ether benign and malignant there are also intermediate
groups implying aggressive local behavior with low to moderate probability for metastasis. Soft
tissue tumors are classified histologically on the basis of the adult tissue they resemble.
Objective: Assessment of radio-pathologic correlation of soft tissue tumors in patients evaluated
at Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia 2019.
Method: The study was conducted at TASH from May 2018-January 2019. Hospital based
prospective cross sectional study was conducted at TASH to address the specific objective during
study period. The Study was conducted among patients being evaluated at Tikur Anbessa
Specialized Hospital oncology department who have both MRI and pathology result during study
period. Data was collected by evaluating the MRI report and biopsy result from oncology
department and also using structured questionnaires. The data was checked for clarity and
completeness. Computerized data analysis was conducted by using SPSS version 25 software.
Result: Total of 73 cases evaluated with 60% malignant. The sensitive MRI parameters for
malignancy are size >5cm (91%), necrosis (82%), bone involvement (80%). The specific MRI
parameters include age>25yr (86%), necrosis (78%), heterogeneous enhancement (75%). From all
the MRI parameters only necrosis had significant correlation with malignancy on imaging in our
study.
Conclusion: The most sensitive and specific MRI parameter to predict malignancy in our study
are size > 5cm, necrosis, heterogeneous enhancement. Necrosis had significant correlation for
malignancy.
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Keywords
Radio-Pathologic correlation ,soft tissue tumors