Dosimetrice valuation of Palliative Hypo fractionated Radiotherapy and its effect on clinical Outcome Inpatients With Vertebral Bone Metastasis Treated at Tikur Anbessa Specialized Hospital,Oncology Center, Addis Ababa,Ethiopia:An Institution -Based Retrospective Cross-Sectional Study.
| dc.contributor.advisor | Dandena,Yonas(Ass.Prof.) | |
| dc.contributor.advisor | Belay,Eskadmas(PhD) | |
| dc.contributor.author | Gulilat,Addis | |
| dc.date.accessioned | 2024-11-28T09:51:00Z | |
| dc.date.available | 2024-11-28T09:51:00Z | |
| dc.date.issued | 2023-12 | |
| dc.description.abstract | Thepurposeofthisstudywastoevaluatedosimetricparametersofthree-dimensional conformalradiotherapy(3D-CRT)andanalyzeitseffectonclinicaloutcomesincludingpain controlandtoxicity.Assessmentofthetreatmentplansinthestudywascarriedoutbasedon reporteddosimetricparameters,whereaspatientreportedpainscoreandtoxicitywereusedfor assessingresponse. Methods:Aninstitution-basedretrospectivecrosssectionalstudywasconductedfrom June– Sept2023.ThedatawascollectedusingKobotoolboxandwasexportedtoSPSSversion26 foranalysis.Statisticaltestsandanalysiswasconducted.Variablesweretastedfor significancep-value<0.05,andifp<0.02multiplelogisticregressionsanalysiswasdoneto determinetheeffectoffactorsontheoutcomevariableandtocontroltheconfoundingfactors. Atotalof97participantswhofulfilledtheinclusioncriteriawereselectedfrom thosepatients treatedusingHypofractionatedradiotherapy(HEBRT)from June1-Sep1,2023.Theywere retrospectivelyevaluatedat2monthsafterforRTpainandtoxicity.PatientreportedPain responsewascalculatedaccordingtointernationalstandardsofpainindexwhichtooktheuse ofanti-painintoaccount;calculatingdailyoralmorphineequivalentdose(OMED). Dose–volumehistogramsforPTV,(V95%,Dmean,Dmin,Dmax,CIandHI),andDoseexposure forOARswasassessed,(lungs,kidney,esophagusandbowl/intestine)dependingonwherethe spinallesionwaslocated,thenresultswerecomparedwithstandardrecommendations.In addition,effectofdosimetryonpainresponseandacutetoxicitywasassessed. Results:Theoverallpainresponsewas63%withcompleteresponse(CR)rateof24.7%.Only 43(44.7%)ofpatientshadreceivedtherecommended95-107%ofprescribeddose.About twentyfivepercent(24.7%)ofpatientshadDmax>110%,thelargestbeing117%.Acutetoxicity wasseenin36(37.1%)ofpatientsfrom these23.4%wassevere.Theconformityindexwas foundtobeb/n1-2in97%ofthecases.Incontrary,homogeneityindexwasdifferentfrom zero in100%ofthecases.OfpatientswhosemeandosewasmeasuredlungDmeanwas>13GYin 2(4.4%)patientswhilekidneyDmeanwas>18GY(EQD2)in1(1.5%).Thereasonforpoor coverage,highDmaxdoseandhighmeandoseforOARsmaybethewrongassumptionof consideringallpalliativepatientsasshortterm survivors,andadvancedpresentationwith diffusevertebralmetastasisresultingdifficultyonplanoptimization. Conclusion:Adeviationfrom recommendedvaluewasseeninD95%,Dmax,DmeanandHI.This suggestsasthereshouldbemoreefforttooptimizeplansandstrictlyevaluatetheDVH.Lack ofsignificancerelationonmultivariateanalysismaybeduetosamplesizeandthosecasesthat hadtoxicitymighthavemissedduetoearlydeath | |
| dc.identifier.uri | https://etd.aau.edu.et/handle/123456789/3710 | |
| dc.language.iso | en_US | |
| dc.publisher | Addis Ababa University | |
| dc.subject | Radiotherapy | |
| dc.title | Dosimetrice valuation of Palliative Hypo fractionated Radiotherapy and its effect on clinical Outcome Inpatients With Vertebral Bone Metastasis Treated at Tikur Anbessa Specialized Hospital,Oncology Center, Addis Ababa,Ethiopia:An Institution -Based Retrospective Cross-Sectional Study. | |
| dc.type | Thesis |