Assessment of Basic Coagulation Profile and Platelet Parameters among type 2 Diabetes Mellitus Patients Attending at Durame General Hospital, Durame, Southeast Ethiopia: Comparative Cross-Sectional Study.
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Date
2024-07
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Addis Ababa University
Abstract
Back ground: Diabetes mellitus is related with disturbances of hemostasis that could subsidize the occurrence of thrombogenic complications. Diabetic patients are exposed to thrombosis abundantly, followed by cardiovascular events, the rest from cerebrovascular events along with peripheral vascular complications, and these is accounted for most of diabetes morbidity, and mortality. The current study was carried out to determine the coagulation profiles of type 2 diabetes mellitus patients in comparison with apparently healthy controls.
Objective: To determine basic coagulation profiles and platelet parameters.
Methods: A comparative cross-sectional study was carried out at Durame General Hospital from June 2023 to January 2024. Socio-demographic and clinical data were collected using questionnaires and checklist. Platelet parameters were determined from EDTA anticoagulated venous blood using ADVIA 560 hematological analyzer, whereas coagulation analysis was done by using ARES LiNEAR coagulation analyzer fom citrated plasma. The data was analyzed using SPSS version 26 statistical software. Kolmogorov-Smirnov test was used to check the data distribution. Independent t-test was used to compare mean between groups, whereas the Kruskal Wallis test was used for comparison of different category in groups. Statistical significance was set at P< 0.05.
Result: There was significant shortening of prothrombin time (PT) (12.9±1.5, vs 13.5±1.3), (p=0.02), and International normalized ratio (INR) (1.08±0.16, vs 1.13±0.17), (p= 0.04) and significant increased of platelet count, MPV (12.1±1.9, vs 10.9±1.5, p
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Diabetes mellitus is related with disturbances of hemostasis that could subsidize the occurrence of thrombogenic complications. Diabetic patients are exposed to thrombosis abundantly