Non-adherence to Antidepressant Treatment and its Predictors among Outpatients with Depressive Disorders, a Hospital-based Ccross-sectional Study in Addis Ababa, Ethiopia
| dc.contributor.advisor | Prof.Araya, Mesfin(MD, Ph.D, Professor of Psychiatry, Department of Psychiatry, AAU) | |
| dc.contributor.advisor | Dr.Milkias, Barkot (MD, Assistant Professor of Psychiatry, Department of Psychiatry, AAU) | |
| dc.contributor.author | Mulugeta, Selam | |
| dc.date.accessioned | 2021-04-08T06:19:58Z | |
| dc.date.accessioned | 2023-11-05T09:32:58Z | |
| dc.date.available | 2021-04-08T06:19:58Z | |
| dc.date.available | 2023-11-05T09:32:58Z | |
| dc.date.issued | 2020-10 | |
| dc.description.abstract | BACKGROUND: In Ethiopia, there is inadequate information on non-adherence to antidepressant treatment in patients with depressive disorders. Having awareness of the pattern of adherence is important in future prognosis, quality of life and functionality in these patients. This study will be conducted to assess the prevalence of Non-Adherence to Antidepressant treatment and its predictors among Psychiatry Outpatients with Depressive Disorders. METHODS: A hospital-based cross-sectional quantitative study was conducted at the psychiatry clinic of Tikur Anbessa Specialized Hospital. A sample of 216 consecutive outpatients with Depressive disorders who visited the Psychiatry clinic since June 2019 and who had at least two visits prior to their last visit were enrolled. Data was collected using questionnaires through inperson and phone call interviews. The eight-item Morisky scale, a scale extensively used in the Ethiopian setting, was used to assess the pattern of medication adherence. Other specially developed tools were used to obtain sociodemographic and clinical information from electronic medical records and patient interviews. Data was analyzed using the Statistical Package for the Social Sciences (SPSS), Version - 25. Univariate and multivariable analyses were carried out to assess factors associated with non-adherence. RESULTS: Ninety percent of the participants who were taking antidepressant medication were found to have a primary diagnosis of Major Depressive Disorder. Based on the 8-item Morisky Medication Adherence Scale, the prevalence of non-adherence was found to be 84.7%. Living distance between 11 to 50 kms from hospital (AOR= 11, 95% CI (29,46.6)), post-secondary level of education (AOR= 8.3, 95% CI (1, 64.4)), taking multiple medications (AOR= 6.1, 95% CI (1, 34.9)) were found to have significantly increased odds of non-adherence. CONCLUSION: The prevalence of non-adherence is very high among patients with depressive disorders. Non-adherence was significantly associated with factors such as increased living distance from the hospital, relatively higher educational level, and polypharmacy. Proper and patent centered psychoeducation to patients, addressing the communication gap between patients and doctors, clinicians’ adherence to prescribing guidelines, avoiding polypharmacy unless indicated, and working on accessibility of treatment for common mental disorders is essential to decrease non-adherence. Larger analytical studies to further establish causal relationships to nonadherence and its impact on depression treatment outcomes are recommended. | en_US |
| dc.identifier.uri | http://etd.aau.edu.et/handle/123456789/25995 | |
| dc.language.iso | en_US | en_US |
| dc.publisher | Addis Abeba University | en_US |
| dc.subject | Medication Adherence, Depressive disorders, Tikur Anbessa Specialized Hospital, Ethiopia | en_US |
| dc.title | Non-adherence to Antidepressant Treatment and its Predictors among Outpatients with Depressive Disorders, a Hospital-based Ccross-sectional Study in Addis Ababa, Ethiopia | en_US |
| dc.type | Thesis | en_US |