Assessment of Effect of Helicobacter Pylori and Helminths Infection on Anemia with Emphasis on Ferritin Level of School Children in Batu Town, Oromia Region, Ethiopia, 2019

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Addis Abeba University


Background: In infants and young children, severe chronic anemia may lead to delayed growth and long term effects on neurodevelopment and behaviour. The main causes of anemia are: dietary iron deficiency; infectious diseases, deficiencies of other key micronutrients or inherited conditions that affect red blood cells (RBCs). Iron deficiency accounts for about 50% of all cases of anemia which results in iron deficiency anemia (IDA). According to the Demography Health Survey, the prevalence of anemia among Ethiopian children under the age of 15 is estimated to be about 24%, classifying it as a moderate public health problem as identified by WHO. Objective: To investigate the effect of Helicobacter pylori and Helminths infection on anemia with emphasis on ferritin level of school children in Batu town, Oromia Region, Ethiopia. Methods: A comparative study was conducted on 161 primary school children aged 4-14 years. Serum samples were collected for serum ferritin level measurement using Beckman Coulter chemistry analyzer. Secondary data on haemoglobin and RBC indices were extracted using format. SPSS version 21 was used to enter and analyze data. Statistical significance was determined between the groups using an independent t-test and a non-parametric Mann-WhitneyU test with a P value less than 0.05. Results: A total of 161 samples were analyzed in this study, with 77 (47.8%) of them being males. Of them, 109 (67.7%) were in the cases group, while 52 (32.3%) were negative for both H. pylori and helminths. There was no statistically significant difference in serum ferritin levels between H. pylori stool antigen positive or H. pylori antibody positive children compared with the control groups, (P=0.787, P= 0.350) respectively. There was no significant effect on serum ferritin as well as hemoglobin, RBC indices between helminths infection when compared with a control group. The serum ferritin level (P=0.286), hemoglobin concentration (P=0.563), MCV (P=0.646), MCH (P=0.485), and MCHC (P=0.975) all increased as a result. Conclusion and Recommendation: The presence of Helicobacter pylori or helminths has no effect on serum ferritin levels or the development of iron deficiency. Cohort studies are recommended for establishing a cause and effect relationship between H.pylori infection or helminths infection and serum ferritin levels.



H.pylori, Helminths, serum ferritin, Anemia, Iron deficiency