Effect of propofol versus thiopentone sodium as an induction agent on prevention of succinylcholine induced fasciculation and myalgia: prospective cohort study

No Thumbnail Available



Journal Title

Journal ISSN

Volume Title


Addis Ababa Universty


Background: - Succinylcholine is a commonly used short acting depolarizing muscle relaxant. It is a relaxant of choice when there is need for quick muscle relaxation of short duration. Though an excellent short acting depolarizing muscle relaxant of choice it still has inherent side effects like postoperative myalgia, muscular fasciculations, hyperkalemia, increase in intra ocular and intra gastric pressure. Out of them post-operative myalgia is the commonly encountered problem that commonly occur in the first 24 hours after succinylcholine administration Objectives. To compare the effect of Propofol versus thiopentone sodium as induction agent on prevention of succinylcholine induced fasciculation and myalgia in adult elective surgical patient from january1,2018 to march 20,2018 G.C in Zewditu memorial Hospital, Addis Ababa, Ethiopia. Methods. prospective, Institutional based cohort study design was conducted on all elective surgical patient who fulfill the inclusion criteria and induced with succinylcholine at Zewditu Memorial Hospital during specified study period. A patient who induced by propofol 3.0mg/kg was taken as Group propofol (n=40) and who induced with Thiopentone sodium 5mg/kg was taken as group thiopentone (n=40). Data was entered in to Epi info version 7 software by investigators and transported to SPSS version 20 statistics window for analysis. Differences of numerical data between groups have been evaluated using independent T-test. Categorical data has been analyzed with the Chi-Square test. A p value of <0.05 was considered as statistically significant. Results: The demographic data of patients in two groups were comparable. The total incidence of succinylcholine induced fasciculation were 18(45%) and 28(70%) in propofol and thiopentone Groups respectively (P=0.007). The severity of fasciculation was reduced more in propofol group than in group thiopentone group (P=0.044). The total incidence of myalgia was 12(30%) V and 21(52.5%) in propofol group and thiopentone group respectively (P=0.048). The severity of myalgia was reduced more in propofol group than thiopentone group (P=0.041). Conclusion and recommendation: Propofol in comparison with thiopentone sodium is effective in reducing the incidence and severity of fasciculation and myalgia. We recommended to use propofol to reduce succinylcholine induced fasciculation and myalgia which currently suffers our patients.