Effect of propofol versus thiopentone sodium as an induction agent on prevention of succinylcholine induced fasciculation and myalgia: prospective cohort study
No Thumbnail Available
Date
2018-01
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Addis Ababa Universty
Abstract
Background: - Succinylcholine is a commonly used short acting depolarizing muscle relaxant. It
is a relaxant of choice when there is need for quick muscle relaxation of short duration. Though
an excellent short acting depolarizing muscle relaxant of choice it still has inherent side effects
like postoperative myalgia, muscular fasciculations, hyperkalemia, increase in intra ocular and
intra gastric pressure. Out of them post-operative myalgia is the commonly encountered problem
that commonly occur in the first 24 hours after succinylcholine administration
Objectives. To compare the effect of Propofol versus thiopentone sodium as induction agent on
prevention of succinylcholine induced fasciculation and myalgia in adult elective surgical patient
from january1,2018 to march 20,2018 G.C in Zewditu memorial Hospital, Addis Ababa,
Ethiopia.
Methods. prospective, Institutional based cohort study design was conducted on all elective
surgical patient who fulfill the inclusion criteria and induced with succinylcholine at Zewditu
Memorial Hospital during specified study period. A patient who induced by propofol 3.0mg/kg
was taken as Group propofol (n=40) and who induced with Thiopentone sodium 5mg/kg was
taken as group thiopentone (n=40). Data was entered in to Epi info version 7 software by
investigators and transported to SPSS version 20 statistics window for analysis. Differences of
numerical data between groups have been evaluated using independent T-test. Categorical data
has been analyzed with the Chi-Square test. A p value of <0.05 was considered as statistically
significant.
Results: The demographic data of patients in two groups were comparable. The total incidence
of succinylcholine induced fasciculation were 18(45%) and 28(70%) in propofol and thiopentone
Groups respectively (P=0.007). The severity of fasciculation was reduced more in propofol
group than in group thiopentone group (P=0.044). The total incidence of myalgia was 12(30%)
V
and 21(52.5%) in propofol group and thiopentone group respectively (P=0.048). The severity of
myalgia was reduced more in propofol group than thiopentone group (P=0.041).
Conclusion and recommendation: Propofol in comparison with thiopentone sodium is
effective in reducing the incidence and severity of fasciculation and myalgia. We recommended
to use propofol to reduce succinylcholine induced fasciculation and myalgia which currently suffers our patients.
Description
Keywords
Succinylcholine,relaxant