Serum Total and Placental Alkaline Phosphatas at Second and Third Trimesters of Normal Pregnant Mothers from July to Nov 2015 at Zewditu Memorial Hospital, Addis Ababa, Ethiopia
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Date
2016-07
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Addis Ababa University
Abstract
Background: Alkaline phosphatase (ALP) (EC 3.1.3.1.) is an enzyme which catalyzes thehydrolysis of phosphate esters at an alkaline PH. Placental alkaline phosphatase isoenzyme(PLAP) has several vital roles during pregnancy for supporting fatal growth and development.The change of PLAP may be associated with high blood pressure, preterm delivery and othercomplication. It could be an indicator of overall placental performance and pregnancy outcomes.Therefore, there is the need to determine and proper interpretation in our local setup.
Objectives: To evaluate serum total and placental alkaline phosphatase at second and thirdtrimesters in normal pregnant mothers in our local setup.
Method: Across-sectional study was done on randomly selected 333 consenting apparentlyhealthy pregnant mothers at Zewditu Memorial Hospital in Addis Ababa, Ethiopia. Maternaldemographic characteristic was obtained through questionnaires and medical chart review. TheTALP and PLAP were analyzed by Human 4-Nitrophenylphosphatas (4-NPP) substrate. Thedata was analyzed using the SPSS software, version 21. The data was assessed using non-parametric analysis; hence the data was found to be skewed. P< 0.05 was considered statisticallysignificant.
Result: The median of TALP and PLAP in second trimester were ( 163 IU/L) and (25 IU/L)respectively while in third trimester were (334 IU/L) and (141IU/L) respectively and at termwere (449 IU/L) and ( 230 IU/L) respectively (P< 0001). Strong positive correlation observedbetween TALP (r2 = 0.805, p<0.001) and PALP with gestational age (r2 = 0.805, P< 0.001). Chi-square showed positive association with blood group and blood pressure (P<0.05).
Conclusion and Recommendation:There was significant increasing serum TALP and PLAP with advancing gestational age. Therewas a peak levels at term. Strong positive correlation observed between TALP and PALP withgestational age. Also, blood group and blood pressure were significantly associated. Thus, itcould be used as an easy accessible and affordable biomarker for monitoring the status ofpregnancy.
Keywords:Total and Placental alkaline phospatase, pregnant mothers Trimester
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Total and Placental alkaline phospatase pregnant mothers Trimester