Survival outcome and Treatment patterns in non-metastatic esophageal cancer patients who underwent curative intent treatment atTikur Anbesa Specialized Hospital, Ethiopia, A3-year retrospective study
| dc.contributor.advisor | Damena Teshome | |
| dc.contributor.author | Woinshet Zegey | |
| dc.date.accessioned | 2026-06-18T14:52:25Z | |
| dc.date.available | 2026-06-18T14:52:25Z | |
| dc.date.issued | 2025 | |
| dc.description.abstract | Background: Esophageal cancer is among the leading causes of cancer-related morbidity and mortality worldwide, with a particularly high prevalence in East Africa. Due to the non-symptomatic nature of the disease at an early stage, patients usually present at an advanced stage. They are either treated with multimodality therapy with curative intent or just palliation of the symptoms once the disease is metastatic. In Ethiopia, most patients are diagnosed at advanced stages, with a substantial proportion being non-metastatic cases that remain eligible for curative treatment. These patients may therefore undergo curative-intent therapies, including surgery, chemoradiotherapy, radiotherapy, or a combination of these modalities. However, local data on treatment patterns and survival outcomes for these patients are lacking. Objective: To evaluate the survival outcome and treatment patterns of non-metastatic esophageal cancer patients treated with curative intent treatment at Tikur Anbesa Specialized Hospital (TASH), Ethiopia, between 2022 and 2025. Methods: A retrospective study was conducted by reviewing the medical records of patients diagnosed with non-metastatic esophageal cancer at TASH during the study period. Data on demographic characteristics, clinical characteristics, treatment modalities, and follow-up outcomes were extracted. Statistical analysis included descriptive summaries of treatment patterns, Kaplan–Meier survival estimates, and the log-rank test. A Cox proportional hazards model was used to identify predictors of survival outcome. Results: One hundred nineteen (119) patients who underwent curative-intent treatment for esophageal cancer at TASH over 3 years were included. The mean age was 51.9 years (SD: 12). Most study participants were females (65, 54.6%) and most of the patients (41, 34.5%) were from the Oromia region. As per the treatment patterns 57 (47.9%) received surgery alone 19 (16%) received CMT…(surgery with NAT/adjuvant therapy) and 43 (36.1%) received definitive RT/CRT. Of those who received CMT, 6 (5%) received surgery and CRT, 5 (4.2%) received surgery and RT, and 8 (6.8%) received surgery and chemotherapy. The median survival was 17 months, 95% CI (14.8, 19.1) The one-year, two-year, and three-year survival rates were 67.8%, 36.6%, and 14.5%, respectively. In the multivariable Cox proportional hazards model, patients who developed treatment related or postoperative complications had a significantly higher hazard of death compared with those without complications (HR=5.97; 95% CI: 2.85–12.5; p<0.001). Conclusion: In Ethiopia, the treatment pattern of non-metastatic esophageal cancer is heterogeneous and not in line with the standard treatment recommendation. And the median survival and the 3-year survival rate are low. Treatment related Complications are a significant determinant of poor survival. | |
| dc.identifier.uri | https://etd.aau.edu.et/handle/123456789/8214 | |
| dc.language.iso | en | |
| dc.publisher | Addis Ababa Uinverstiy | |
| dc.subject | Non-metastatic esophageal cance | |
| dc.subject | treatment patterns | |
| dc.subject | Curative treatment | |
| dc.subject | Survival outcomes | |
| dc.subject | retrospective study | |
| dc.subject | Ethiopia | |
| dc.title | Survival outcome and Treatment patterns in non-metastatic esophageal cancer patients who underwent curative intent treatment atTikur Anbesa Specialized Hospital, Ethiopia, A3-year retrospective study | |
| dc.type | Thesis |