Evaluation of Hematological and Biochemical Profiles among Pregnant Women with Pregnancy Induced Hypertension Attending in St. Peter Hospital, Addis Ababa, Ethiopia
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Date
2024-06-13
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Addis Ababa University
Abstract
Background: Pregnancy-induced hypertension (PIH) is a major pregnancy condition that raises the mother's and the newborn's risk of illness and death. The aim of this study is to evaluate the hematological and biochemical characteristics of pregnant patients hospitalized to St. Peters hospitals in Ethiopia who have pregnancy-induced hypertension.
Objective: To evaluate hematological and biochemical profiles of pregnant women at St. Peter hospital. Methods: A comparative case control study was carried out between August and October of 2022 among 125 pregnant women with pregnancy-induced hypertension and 125 normotensive women at St. Peter hospital. Through the use of standardized questionnaires and interviews with pregnant women, sociodemographic data was gathered. The complete blood count and biochemical profiles of women were determined from venous blood using Beckman Culter DXH 800 UniCel hematological analyzer and COBAS C311 analyzer, respectively. SPSS version 26.0 statistical software was used to analyze the data. Clinically relevant variables were those whose P-value was less than 0.05 and whose level of statistical significance was defined at a 95% confidence interval.
Result: Alkaline phosphatase (ALP) (119.34±74.66), Alanine transaminase (ALT) (26.71±42.93), and Aspartate transaminase (AST) (36.8±47.43) values were significantly higher in pregnancy-induced hypertension than in controls (ALP = 90.53±68.32, ALT = 14.94±1.91, and AST = 21.40±12.81, respectively). Hemoglobin, hematocrit, and platelet levels were significantly lower than in controls (Hgb: 13.47±1.6 vs. 13.72±0.81, HCT: 37.87±4.3 vs. 39.23±2.52, and PLT: 187.51±78.69 vs. 222.34±78.44). Potassium levels were significantly lower in pregnancy-induced hypertension patients than in controls (4.18±0.41 vs. 4.65±0.57 mg/dL). White blood cell (WBC) count and neutrophil levels were significantly higher in pregnancy-induced hypertension patients than in controls (WBC: 9.48±4.3 vs. 7.92±2.5 mg/dL). Conclusion: This study showed that pregnant women with PIH had higher levels of ALP, ALT, and AST. The amount of neutrophil was significantly higher. Pregnant women with PIH had significantly decreased levels of Hgb, HCT, and PLT. So it was recommended clinicians use hematological profiles and biochemical tests along with measuring the blood pressure of pregnant mothers to prevent them from PIH effect. Key word: Hematological profile, anemia, thrombocytopenia, and pregnant women
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Hematological profile anemia thrombocytopenia and pregnant women