Prevalence of Anemia and associated factors in Heart failure with reduced ejection fraction patients attending Tikur Anbessa specialized Hospital Cardiac Clinic from June 1- October 30
No Thumbnail Available
Date
2020-12
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Addis Abeba University
Abstract
Background: Anemia is one of the common comorbidities in heart failure patients with
reduced ejection fraction and its presence is associated with decreased functional
capacity, poor quality of life, an increase in the rate of hospital admission, and increased
mortality. Previous studies have estimated the prevalence of anemia in heart failure
patients to be 10-50%. Older age, renal dysfunction, female sex, and advanced NYHA
functional class are reported to be independently associated with anemia. Anemia is a
prevalent problem in the Ethiopian setting affecting 23% of reproductive-age women, and
18% of adult men. But data is lacking about its prevalence and factors associated with it
in heart failure patients with reduced ejection fraction in our set up.
Objective: To assess the prevalence of anemia and associated factors in heart failure
patients with reduced ejection fraction on follow-up in the cardiac clinic of TASH with a
clinical diagnosis of HFrEF from June 1 –October 30.
Method- A hospital-based prospective cross-sectional study was conducted by
interviewing HFrEF patients who came to the cardiac clinic during the study period and
reviewing their i-care records. CBC and renal function tests were done for these patients
and the results were collected. History of diabetes, etiology of HF, use of ACEI/ARB and
admission in the past 6 month was assessed from the patient’s i-care records and patient
interviewing. Quality of life assessment was done using Amharic version of KCCQ-12
questioner. EF was taken from previous echo reports documented on icare records.
Patient’s demographic data, laboratory parameters and KCCQ-12 score were collected
using a structured checklist. The data collected was cleared, entered and analyzed using
SPSS software version 20. The research was conducted with an estimated total budget of
27,148.00 birr.
Result- Among 138 HFrEF patients 27(19.8%) patients had anemia. Anemic patients had
a lower quality of life as indicated by lower KCCQ-12 score (34 vs 43) (p=0.004), a
higher rate of admission history within 6 months prior to presentation. (44% vs 12.6%)
(p=0.041) and lower mean eCrCl(75 vs 87ml/min)(P=0.046). On binomial logistic
regression, male sex is also found to be an independent predictor of anemia in this
study(p=0.002) but no strong association was found with the age of patients, the presence
of diabetes, etiology of HF, and the use of ACEI/ARBs. Anemic patients also tend to
have more NHYA class III HF than Class II HF.
Description
Keywords
Anemia, heart failure with reduced ejection fraction, KCCQ-12 score