Comparative Study on Pathological Changes in the Small Intestine of Sheep and Goat Experimentally Infected with Trichostrongylus Colubriformis
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2020-06
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Abstract
The experimental study design was conducted to determine hematological and serum biochemical parameters and pathological changes in the small intestine of sheep and goat experimentally infected with T. colubriformis in fly-proof experimental facility at College of Veterinary Medicine and Agriculture, Bishoftu, Ethiopia. During the study period, 13 sheep (6 controls, 7 infected) and 14 goats (7 controls, 7 infected) were included in the experiment. The infective larvae of T. culibriformis (L3) as a single dose of 10,000 per-animal was administered orally to infected sheep and goats (G2 and G4). From the infected group, the total recovered mean worm burden was recorded higher in infected goat (5016 larvae of T. colubriformis) (P<0.05) than infected sheep (3446 larvae) with establishment rate of 50.16% and 34.46% respectively. The total mean hematological and biochemical values recorded in infected and uninfected sheep and in infected and uninfected goat were significantly (P<0.05) lower in infected than uninfected control, except RBC and WBC count. In sheep PCV, Hb and albumin were significantly (P<0.05) lower in infected group than uninfected control group. Gross lesions found in the intestine were enteritis with petechial hemorrhages, edema, hyperemia and mucosal slough which were marked in the duodenum (62.69%) and jejunum (33.33%) in sheep and 47.05% duodenum and 45.09% jejunum in goat. The microscopic lesions developed by T. colubriformis were subtotal villus atrophy, hemorrhage, straighten and elongated dilated crypts, loss of epithelium, mucosa erosion and infiltration of inflammatory cells. In conclusion, the present experimental investigation showed that T. colubriformis infection affected hematological parameters, biochemical indices and caused pathological changes of small intestine in sheep and goat, with more severe infection in goats than sheep although they were under the same management condition.
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Control, experimental infection, intestine, lesions, sheep and goat, T. colubriformis