Histologic Type, Treatment Pattern, Outcome and Factors Associated with Treatment outcome of Esophageal Cancer Patient treated at Tikur Anbessa Specialized Hospital Addis Ababa, Ethiopia 2010-2016: A Cross -Sectional Study.

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Addis Ababa Universty


Background: Esophageal cancer is the eighth leading cancer case and the top sixth cause of cancer mortality worldwide. In Ethiopia esophageal cancer ranks the seventh and eighth as the leading cause of cancer mortality and morbidity respectively according to Globocan 2012 estimate. Objectives: The objective of this study is to assess histologic type, treatment pattern, outcome and factors associated with treatment outcome of esophageal cancer Patients at Tikur Anbessa Specialized Hospital Addis Ababa, Ethiopia. Methods: A retrospective cross sectional study using record review was employed at surgical oncology department, radiotherapy and chemotherapy treatment center of Tikur Anbessa Specialized Hospital. All newly confirmed esophageal cancer patients (n=349) who were registered at Tikur Anbessa Specialized Hospital from January 2010 to December 2016 were included in this study. Patients chart was reviewed and telephone interview was made to generate all variables required for the study from March to April 2017.Finally basic descriptive statistics ( frequency ,mean , median and tables ), bivariate and multivariable analysis was performed and statistical significance were ascertained with 95% CI at 0.05 alpha level. Result: A total of 349 esophageal cancer patients charts were reviewed. From a total of cases that were registered during seven years period there were 287 (90.3%) cases of squamous cell carcinoma. Surgery was done for 183(52.4%) of cases, 89(25.5%) received chemotherapy and 26 (7.4%) took radiotherapy which is palliative type. From all esophageal cancer patients who were included in this study 310 (88.8%) were not alive at a time of the study period. Only Chemotherapy (AOR 2.80(95%CI of 1.22, 6.41) and surgery (AOR 0.287 (95%CI 0.126, 0.625) were found to be factors associated with death from esophageal cancer. Conclusion: squamous cell carcinoma was the most predominant histologic type followed by adenocarcinoma affecting males and females equally. Most of the esophageal cancer patients were diagnosed in advanced stages affecting the treatment outcome of esophageal patients. Surgery was the most frequent treatment modality in the hospital, overall sex of patients, surgery and chemotherapy has significant association with treatment outcome of esophageal cancer patients.



Esophageal Cancer, treatment pattern , Treatment Outcome, Histologic Type, TASH, Addis Ababa, Ethiopia