Clinical Characteristics, Treatment, Outcome and Associated Factors of Acute Lymphoblastic Leukemia Patients Admitted to Hematology Ward of Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia 21 Months Prospective, Observational and Cross Sectional Study
| dc.contributor.advisor | Binyam Barega | |
| dc.contributor.author | Fisihatsion Tadesse | |
| dc.date.accessioned | 2025-08-07T07:26:07Z | |
| dc.date.available | 2025-08-07T07:26:07Z | |
| dc.date.issued | 2024-01-13 | |
| dc.description.abstract | Background: Acute lymphoblastic leukemia is one of the commonest referral diagnoses to TASH. Due to need of urgent diagnosis and treatment, there is currently a need to improve the service given to manage this type of leukemia. Patients treated for ALL in this center have usually poor outcome. There is a need to identify the gap in diagnosis and management of this disease and this study aims to fill that gap. Objective: The primary objective of this study is to assess the outcome and its associated factors among adult ALL patients admitted to hematology ward of TASH. Methods and materials: This is a prospective, cross sectional and observational study that was conducted on ALL patients admitted to hematology ward of TASH. The study period was from January 01/2023 to September 30/2024. Result: a total of 174 ALL patients were admitted to hematology ward of TASH from January 1/2023 to July 31/2024. 101 (58%) were males and 73 (42%) were females. M: F ratio was 1.4. The age range of patients was from 15 years to 78 years. The mean age was 31.4 (SD ± 14.74), the median was 28. The most common presenting symptom was symptoms of anemia, which were present in 92% of patients. Constitutional symptoms (70.1%) and fever (53.4%) were the next common symptoms. Pallor was the commonest sign seen in 87.4% of patients. LAP and splenomegaly were seen in 43.1% and 37.4% of patients respectively. The mean WBC count was 58, 760 (SD ± 87,059). The mean hemoglobin level was 7.71g/dl (SD ±3.025) and the mean platelet count was 60,736 (82,969 ± 82,960). 19 patients have t (9,22) positive.112 (64.4%) of patients were started on induction CHT and 74 (66%) achieved CR. The most commonly induction regimen was CALGB 10403. 14 (8%) of patients were started on palliative therapy. On the final data cut of date, September 30/2024, 36 patients were alive and there were 86 documented deaths. The most common cause of death was sepsis and septic shock. This was the cause of death in 83.7 of cases. Conclusion: ALL is a common referral diagnosis to TASH with clinical signs and symptoms similar with reports from other studies. Treatment results were notable for low CR rates; high induction mortality and frequent loss from followup. | |
| dc.identifier.uri | https://etd.aau.edu.et/handle/123456789/6233 | |
| dc.language.iso | en_US | |
| dc.publisher | Addis Ababa University | |
| dc.subject | Treatment Outcome and Associated Factors of Acute Lymphoblastic Leukemia | |
| dc.subject | ||
| dc.title | Clinical Characteristics, Treatment, Outcome and Associated Factors of Acute Lymphoblastic Leukemia Patients Admitted to Hematology Ward of Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia 21 Months Prospective, Observational and Cross Sectional Study | |
| dc.type | Thesis |