Establishment of Lipid Profile and Major Electrolytes Reference Interval in Apparently Healthy Adults and Pregnant Women in Addis Ababa, Ethiopia.
| dc.contributor.advisor | Kindie Samue | |
| dc.contributor.advisor | Tsegaye Aster | |
| dc.contributor.author | Aboneh Fikirte | |
| dc.date.accessioned | 2025-08-12T19:49:02Z | |
| dc.date.available | 2025-08-12T19:49:02Z | |
| dc.date.issued | 2022-06 | |
| dc.description.abstract | Background: Reference Interval is value obtained by measurement of a particular type ofquantity on an individual belonging to a reference group. It is very important in clinicalmanagement of patients, maternity follow-up, and monitoring of clinical trials before onset ofserious adverse events. In Ethiopia, similar to most developing country laboratory test results areinterpreted by using reference intervals which developed for western population .Differentfactors make the application of western RI during the interpretation of laboratory result leads tounnecessary exclusion of eligible participants, contribute to over reporting of adverse events andincrease the number of referrals for clinical investigations. Despite its significance, there havefew efforts to establish these tools. Thus, the current study aimed to address the gaps in serumlipid profile and selected electrolytes reference intervals by determining variability with genderamong adults and pregnant women in Addis Ababa. Objective: To establish lipid profile (TC, TG, HDL-C, LDL-C) and selected electrolytes (Na, K,Cl) reference interval for apparently healthy adults and pregnant women in Addis Ababa,Ethiopia. Methods: The present community cross-sectional study was conducted from March 1 to June 30,2020. A total of 522 individuals with age of ≥18 years and pregnant women ≥15 years that livedin the city of Addis Ababa were recruited. After demographic information and a brief medicalhistory of the adults were collected by using questionnaires, important physical examination, andanthropometric measurement were done. Serum lipid profile and selected electrolytes valueswere determined using Cobas c501 chemistry analyzer. SPSS version 23 and Med Calc ver20.008 software were used for reference limits determination for adults and pregnant women. Results: Established reference interval for adult female and male adult were; TC [ (120.4-272)and (100.1-243) mg/dl], TG [(51-164) and (46.5-170)mg/dl ]; HDL-c [(25-57) and (16-52.7)mg/dl], LDL-[(51-170) and (35-162)mg/dl]; Na [(138-149)and (138-150)mmo/l]; K[(3.9-5.6)and(3.9-5.5 ) mmol/L] and Cl [(101-112)and (99.14-108) mmol/l ]. For pregnant womenestablished RI of lipids and major electrolyte were TC(118-275) mg/dl, TG (64 -304) mg/dl,HDL ( 22-62.5 )mg/dl, LDL(47.8-167)mg/dl, Na(136-143) mmo/l, K(3.65-5.1 ) mmol/L,Cl(100.5-108) mmol/l.Also statistically significant difference was seen for TC, TG, HDL, LDL and Cl between maleand female and for TC, TG, Na and K between adult females and pregnant women. Conclusion: The current study established RI to be used for adults and pregnant women ofAddis Ababa. There was a difference between the present established reference interval andother reported studies. Thus high or low value seen for lipids (TC,TG and LDL) and electrolyte.Also the value of HDL-c was very low. Significant differences were also seen between gendersfor most of the analyte, which alerts for further large scale studies, and need careful verificationof test kit manufactures’ given values before directly used for the desired purpose | |
| dc.identifier.uri | https://etd.aau.edu.et/handle/123456789/6459 | |
| dc.language.iso | en_US | |
| dc.publisher | Addis Ababa University | |
| dc.subject | Adult Reference Intervals Lipid profile Electrolyte Female Male Pregnant. | |
| dc.title | Establishment of Lipid Profile and Major Electrolytes Reference Interval in Apparently Healthy Adults and Pregnant Women in Addis Ababa, Ethiopia. | |
| dc.type | Thesis |