Early Pregnancy Mean Arterial Pressure and Maternal Risk Factors for Prediction of Preeclampsia among Women who Delivered at three Teaching Hospitals in AA, Ethiopia: a Case Control Study
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Date
2024-10-10
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Addis Ababa University
Abstract
Background: -The diagnosis of PE is made based on high blood pressure and proteinuria after 20 weeks of gestation of pregnancy in previously normotensive women. The best combined first trimester screening studies for PE is one that includes maternal risk factors, measurements of mean arterial pressure (MAP), serum placental growth factor (PLGF), and uterine artery pulsatility index (UTPI).
Objective: -To look the relationship of early pregnancy mean arterial pressure and maternal risk factors for prediction of preeclampsia among women who delivered at three teaching hospitals in AA, Ethiopia:
Method: -The research design was a case control study and all women having early antenatal visit and recording blood pressure in the study area were included. Sample size is calculated by using double population proportion formula and with the case to control ratio will be 1:2.
Result: - In this study the prediction of preeclampsia using MAP by AUC and ROC MAP=0.698, 95% CI=0.637, 0.759). The sensitivity of MAP in predicting PE was 51.8%, and specificity of 78.6%. Positive predictive value of MAP was 54.18% and negative predictive value was 76.5%. Other determinates of preeclampsia were study participant whose age of ≥35 years compared to those of age 18-24 years, having a history of preeclampsia and mean arterial pressure of ≥90. ix
Recommendation: - Given the moderate predictive performance of MAP, SBP, and DBP in early pregnancy, these measures should be routinely monitored and used as part of a comprehensive preeclampsia screening strategy.
Keyword: - preeclampsia, mean arterial pressure, pregnant women
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Keywords
preeclampsia, mean arterial pressure, pregnant women