Demographic, Clinical, Pathologic and Treatment Pattern of Soft Tissue Sarcoma at Tikur Anbessa Specialized Hospital,Ethiopia.
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Date
2022-02
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Addis Ababa University
Abstract
Abstract
Soft tissue sarcomas are an uncommon group of neoplasm that could be fatal, especially in the metastatic setting. Late presentation, Missed Diagnosis and inadequate treatment may worsen clinical outcomes. There is lack of evidence on the demographic, pathological, Clinical and treatment pattern of soft tissue sarcoma in developing countries like Ethiopia Thus, this study is aimed to assess the demographic, pathological, Clinical and treatment patterns of soft tissue sarcoma in a single tertiary health institution in Ethiopia.
Objective: The aim of this study is to assess demographic, pathologic, clinical and treatment pattern of soft tissue sarcoma at Tikur Anbesa Specialized hospital at four years duration.
Methods :This is a retrospective cross-sectional study that asses demographic, clinical,pathologic and treatment pattern of soft tissue sarcoma at the TASH between august 2017 and August 2021 G.C. This period was selected because most patient data before this are not available according to my pilot study.
Result: A total of 320 patients were registered from August 2017 to August 2021 and 190 patients card were available for this study and 80 of patients were excluded according to exclusion criteria and 50 of patients’ card were lost. The median age was 32 years of age and Male sex was commonly affected accounting 61.6% and female sex accounts 38.4%. The commonest sites were extremities accounting for 48.9 % of cases. The Commonest presenting symptoms were mass and pain accounting for 93.2% and 77.9% of cases respectively. The commonest histology subtypes were, un differentiated sarcoma, rhabdomyosarcoma and synovial sarcoma accounting 50%, 15.8% and 6.3 % cases respectively. The grade of the lesions was described in 67.3 % of patients. Of those lesions whose grade was described 56.8 % were high grade lesions. From all cases 58.3% of the patients underwent surgery as a primary treatment modality. Only 50.5% of cases were started treatment with curative intent and 49.5% of the case started their treatment with palliative intent.
Conclusion: The pattern of soft tissue sarcoma in this cross sectional study has shown different distribution in terms of demography, clinical presentation, treatment and pathological subtypes when compared to other studies.
Advanced stage of initial clinical presentation and substandard work up according to standard text books and therapy makes it unique from cases reported from other parts of the world
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Soft tissue Sarcoma