A Comparison of Hypoglycemic Effect in Diabetic Mice and Total Phenolic Content of Leaves Extract of Moringa Stenopetala and Moringa Oleifera

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Addis Ababa University


Diabetes is a defect in the body's ability to convert glucose (sugar) to energy. It develops either when the pancreas fails to produce sufficient quantities of insulin or the insulin produced is defective. This metabolic disorder is characterized by hyperglycemia (fasting blood glucose level greater than 126 mgj dl taken on at least two separate occasions). Medicinal plants are used in the traditional medical practice to treat diabetes mellitus in different part of the world. Moringa sp. has been documented to have medicinal importance against various illnesses. The present study was conducted to compare the anti-diabetic activity and total phenolic content of two species of Moringa; namely M. stenopetala and M. oleifera leaves extracted with methanolwater and further with ethyl acetate as fraction. The anti-diabetic activity was studied by repeated oral dose administration of the extract of the leaves and the fraction in Streptozotocin induced mice. The mice were grouped into six groups; Moringa stenopetala methanol-water extract treated, Moringa stenopetala ethyl acetate fraction treated, Moringa oleifera methanol-water extract treated, Moringa oleifera ethyl acetate fraction treated, Standard diabetic drug treated and Diabetic control. The diabetic mice received the extract and the fraction of both leave daily for 21 days. The result showed that ethyl acetate fraction of Moringa stenopetala treatment resulted in significant reduction of fasting blood glucose level initially was 190.6±3.4351 mgj dl and it reduced to 129±1.8708mgj dl and 109±4.6368mgjdl respectively after 14 and 21 day administration. Also this fraction has potential antioxidant activity and remarkable amount of phenolic concentration. The result indicated that M. stenopetala leaves are suitable source of green leafy vegetable to reduce the diabetic complications in diabetic patients. Key words: anti-hyperglycemic, phenolic, diabetes, antioxidant, Moringa stenopetala, Moringa oleifera



anti-hyperglycemic, phenolic, diabetes, antioxidant, Moringa stenopetala, Moringa oleifera