Seroprevalence and Risk Factors of HBV, HIV and Syphilis Infections among Pregnant Women Attending at Gandhi Memorial Hospital, Addis Ababa, Ethiopia.

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Addis Abeba University


Background: HIV, viral hepatitis, and Syphilis infection among pregnant women have a serious outcome on maternal and newborn baby in worldwide. Sexually transmitted infections cause considerable morbidity worldwide, especially among women. and as hidden epidemics of tremendous health and economic consequence in the world. Objective: to determine Seroprevalence & risk factors of HIV, HBV, and Syphilis Infection among pregnant women attending Gandhi Memorial Hospital, Addis Ababa Ethiopia from March to June, 30 2021. Methods: Hospital-based cross-sectional study was conducted among 384 pregnant women from March to June,, 2021. A structured questionnaire was used to collect socio-demographic characteristics and predictors of HIV, hepatitis B, and Syphilis infections through face-to-face interviews. A venous blood sample of 5mL was collected from study participants, and then Separate serum was screened for anti-HIV, HBsAg, and Trepollema pallidum antibodies using rapid test kits and further Verified by Wanti enzyme-linked immunosorbent assay. The data were entered using Epi Info version 7.2.4 and exported to SPSS version 25, and Logistic regression analysis was used to identify predictors of HIV1/2, hepatitis B, Syphilis infections. A p-value less than 0.05 was considered statistically significant. Results: The overall seroprevalence of HIV1/2, Hepatitis B, and Syphilis infections were (3.9%), (3.4%) and (2.3%), respectively. In multivariate analysis, The prevalence of HIV was significantly higher in More than one Sex Partners [AOR 3 95%CI (1.4 - 6.1)], [p=<0.002], and The risk for HBV infection more than one Sexual partner [4.3 95%CI (1.17- 8.3],[p=0.003]. The risk for syphilis occurrence was significantly higher among the history of More than one Sex Partners [AOR 3 95%CI (1.2 - 5.2)], [p=<0.001]. HIV co-infection was present in 23.1% and 44.4% of hepatitis B virus and Treponema pallidum positive pregnant women respectively. Conclusion: Overall, prevalence of syphilis and HIV were relatively higher with a young women andin womenliving in Addis Ababa, HBV infection was higher only in Non educated women, More than one Sex partner is a Major predictor of STI infections. Therefore;Equal attention is Needed to HBV and syphilis infection like HIV to control further transmission and the associated morbidity and mortality .



Sero-Prevalence ofHIV1/2, HBsAg &Syphilis, and risk factors, in pregnant women. Horizontal and vertical transmission.