Seroprevalence and Risk Factors of HBV, HIV and Syphilis Infections among Pregnant Women Attending at Gandhi Memorial Hospital, Addis Ababa, Ethiopia.
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Date
2021-09
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Addis Abeba University
Abstract
Background: HIV, viral hepatitis, and Syphilis infection among pregnant women have a serious
outcome on maternal and newborn baby in worldwide. Sexually transmitted infections cause
considerable morbidity worldwide, especially among women. and as hidden epidemics of
tremendous health and economic consequence in the world.
Objective: to determine Seroprevalence & risk factors of HIV, HBV, and Syphilis Infection
among pregnant women attending Gandhi Memorial Hospital, Addis Ababa Ethiopia from
March to June, 30 2021.
Methods: Hospital-based cross-sectional study was conducted among 384 pregnant women from
March to June,, 2021. A structured questionnaire was used to collect socio-demographic
characteristics and predictors of HIV, hepatitis B, and Syphilis infections through face-to-face
interviews. A venous blood sample of 5mL was collected from study participants, and then
Separate serum was screened for anti-HIV, HBsAg, and Trepollema pallidum antibodies using
rapid test kits and further Verified by Wanti enzyme-linked immunosorbent assay. The data were
entered using Epi Info version 7.2.4 and exported to SPSS version 25, and Logistic regression
analysis was used to identify predictors of HIV1/2, hepatitis B, Syphilis infections. A p-value
less than 0.05 was considered statistically significant.
Results: The overall seroprevalence of HIV1/2, Hepatitis B, and Syphilis infections were
(3.9%), (3.4%) and (2.3%), respectively. In multivariate analysis, The prevalence of HIV was
significantly higher in More than one Sex Partners [AOR 3 95%CI (1.4 - 6.1)], [p=<0.002], and
The risk for HBV infection more than one Sexual partner [4.3 95%CI (1.17- 8.3],[p=0.003]. The
risk for syphilis occurrence was significantly higher among the history of More than one Sex
Partners [AOR 3 95%CI (1.2 - 5.2)], [p=<0.001]. HIV co-infection was present in 23.1% and
44.4% of hepatitis B virus and Treponema pallidum positive pregnant women respectively.
Conclusion: Overall, prevalence of syphilis and HIV were relatively higher with a young
women andin womenliving in Addis Ababa, HBV infection was higher only in Non educated
women, More than one Sex partner is a Major predictor of STI infections. Therefore;Equal
attention is Needed to HBV and syphilis infection like HIV to control further transmission and
the associated morbidity and mortality .
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Keywords
Sero-Prevalence ofHIV1/2, HBsAg &Syphilis, and risk factors, in pregnant women. Horizontal and vertical transmission.