Magnitude and Associated Risk Factors Of Possible Fungal Infection Among HematoOncology Patients With Neutropenia at Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia

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Addis Abeba University


Background A fungal infection represents a growing problem i n children with hematologic mali gnancies duri ng chemotherapy-induced neutropenia. Objectives: This study ai med to evaluate the magnitude of possible fungal infection among hemato-oncologic children admitted to the hospital between 2017 and 2021 in TASH, Ethiopia. Methods: Institution-based retrospective cross-sectional study reviewed the charts of 256 neutropenic patients at Ti kurAnbessa specialized hospital. Required data were collected using a questionnaire. The data were entered i nto a computer usi ng Excel and exported to Statistical Package for Social Sciences Version 25 for analysis. Binary logistic regression analysis assessed predicting factors associated with a fungal infection, and p-value <0.05 was considered statistically signi ficant. Results: Among 256, 152 were males, and most of the patients were in the age range of 5-10 years. In this study, the magnitude of fungal infection among haemato-oncology neutropenic patients was 31%. Among those patients diagnosed with a possible fungal infection, 56 (72%) ALL patients, 6 (7.7%) AML patients and 15 (19%) of NHL patients. Age, duration, and severity of neutropenia and prolonged use of steroids are significantl y associated factors. Conclusion: Our fi nding suggests a high rate of fungal infections in neutropenic ALL and AML patients. These results help i mprove the management of these patients. However, fur ther studies are needed.



Neutropenia, Invasive fungal infection, hemato-oncology, pediatrics