The Burden and Determinates of anemia among predialysis chronic kidney disease patients following in renal unit at Tikur Anbessa Specialized Hospital
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Date
2021-02
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Addis Abeba University
Abstract
Background: Anemia is common and significant complication of chronic kidney disease
(CKD). Anemia of chronic kidney disease is associated with significant cardiovascular morbidity
mortality and poor quality of life. However, its prevalence and management has not been studied
thoroughly at local and national level.
Objective: To assess the prevalance, severity and management of anemia among predialysis
chronic kidney disease (CKD) patients on follow up at Tikur Anbessa Specialized hospital
(TASH) renal clinic.
Methods and Materials: A hospital based cross sectional hospital study was conducted from
April 1 to July 30, 2020. Consecutive sampling was used to recruit 100 study participants.
participants were interviewed using structured questionnaire, and their medical records were
reviewed to obtain information on relevant medical history and laboratory parameters. Serum
Iron panel was determined for all enrolled patients. Data was analyzed using SPSS version 26.
Continuous variables were presented as means ± standard deviations and compared by t-test.
Categorical variables were expressed as count with percentage and compared by Chi-square.
Bivariate and multivariate logistic regression analyses were used to identify independently
associated factors of anemia. P-value <0.05 was used to declare association.
Results: the burden of anemia in CKD was high (48%) and its prevalence increased with
worsening kidney function. Diabetes (40%) and hypertension (25%) were the leading causes of
CKD. CKD stage, iron marker and BMI were found to be independent determinant of anemia
among CKD patients. Among patients with anemia, only 35.4% were treated, only 27% of
patients were managed with iron agent and only 8.3% were managed with ESA.
Conclusion: Screening and intervention programs should be implemented to improve the
outcome of CKD patients with anemia.
Grant source: Addis Ababa University, college of health sciences, school of medicine
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Keywords
Chronic kidney disease, anemia, Ethiopia.