Molecular Characterization and Antimicrobial Resistance Profile of Diarrheagenic Escherichia Coli In Under-Five Children in Central Ethiopia
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Date
2024-06-13
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Addis Ababa University
Abstract
Many children fail to reach their development milestones due to several
infection-related health problems in developing countries. One major infection-related health
problem in under-five children (UFC) is diarrhea with the highest mortality rate in sub-
Saharan Africa including Ethiopia. Diarrheagenic Escherichia coli (DEC) is the major causes
of diarrhea in UFC. Emergence of antimicrobial resistance (AMR) among DEC and other
diarrheagenic bacterial strains including extended-spectrum ß-lactamase (ESBL) and
carbapenemase producing E. coli strains are among the major threats to health globally. DEC
pathotypes have emerged due to genomic plasticity of the E. coli and are associated with
different life-threatening clinical diseases. The epidemiology of DEC and their AMR profile
and the genetic background of DEC are not well characterized in Ethiopia. The present study
aimed to determine molecular epidemiology and AMR profile of DEC and to provide some
genetic insight of DEC pathotypes isolated from UFC from Central Ethiopia
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Keywords
Molecular Characterization and Antimicrobial Resistance