Internal Medicine

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Browsing Internal Medicine by Subject "adverse drug reactions cutaneous adverse drug reactions"

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    Patterns of Cutaneous Adverse Drug Reactions and Most Common Incriminated Drugs at ALERT Hospital, Addis Ababa, Ethiopia: A Five Year Retrospective Study
    (Addis Ababa University, 2023-12-04) Mekdes Abebaw; Bethlehem Mehari
    Background: Adverse drug reactions (ADR) is "any unpleasant and unanticipated reaction to a drug that could occur at levels utilized for prevention, diagnosis, or therapy. Cutaneous adverse drug reactions (CADRs) form an important clinical entity in dermatology practice and the severity of such reactions vary from mild to fatal ones. The common culprit drug class to CADRs includes antinfection drugsnonsteroidal antinflammatory drugs (NSAIDs), antiepileptics, and iodinated contrast media. Objectives: The objective of this study is to determine the pattern ofcutaneous drug reaction and most incriminated drugs in patients who visited ALERT dermatology clinic, Addis Ababa, Ethiopia, from January 2017 to December 2022 GC. Methods: A hospital based retrospective crossectional study was conducted at ALERT center on patients who visited the dermatovenerology clinic from January 2017 to December 2022 and were diagnosed with cutaneous drug reaction. A structured data collection checklist was used to assess medical charts. Data was analyzed by using SPSS version 27. Frequency distributions, percentages, tables and charts were used to show descriptive results. Associations were computed using chi square test. Result: A total of 67 patients (58.21% females and 41.79% males) were included in the study. Mean age was 27.63 years. The most common CADRs observed in the study were FDE comprising 64.2% of patients followed by MPE accounting for 16.4% and lichenoid drug eruption making up 7.5% of the cases. The most common incriminated drugs noted in the study were cotrimoxazole (11.9%) followed by NSAIDs and others (7.5% each) and fluoroquinolones (6%). CADRs to unspecified drugs were found in 53.7% of the cases. Conclusion: The CADRs patterns seen in our study are fairly different from others. Our study has provided baseline information about the proportion of CADRs in our practice and their morphological distribution among different age group, genders, and causative drugs. Key words : adverse drug reactions, cutaneous adverse drug reactions