Pharmacology

Permanent URI for this collection

http://etd.aau.edu.et/handle/123456789/80

Browse

Browsing Pharmacology by Subject "Analgesic activity"

Now showing 1 - 2 of 2
  • No Thumbnail Available
    Item
    Evaluation of Analgesic and Anti-Inflammatory Activities of Solvent Fractions of the Leaves of Moringa Stenopetala Bak.F. In Swiss Albino Mice
    (Addis Ababa University, 2014-05) Tamrat, Yohannes; Nedi, Teshome (PhD); Shibeshi, Workineh(PhD)
    Many people still experience pain and inflammation regardless of the available drugs for treatments. In addition, the available drugs have many side effects, which necessitated a quest for new drugs from several sources with medicinal plants being one of them. This study evaluated the analgesic and anti- inflammatory activity of the solvent fractions of Moringa stenopetala. Successive soxhlet and maceration were used as methods of extractions and Chloroform, methanol and water were used as solvents. Radiant tail flick latency, acetic acid induced writhing and carrageenan induced paw edema models were used to assess the analgesic and anti-inflammatory activities. The test groups received different doses of the three fractions 100 mg/kg, 200 mg/kg and 400 mg/kg. The positive control groups received either Morphine 20 mg/kg or Aspirin at 100 mg/kg or 150 mg/kg. The control groups received the vehicles distilled water or 2% Tween80, 10 ml/kg. In all models the chloroform fraction had protections only at a dose of 400 mg/kg. But, the methanol and aqueous fraction at all doses have shown a significant central and peripheral analgesic and anti-inflammatory activity having comparable effects with standards. Phytochemical screening test revealed differential distribution of secondary metabolites amongst the fractions and the metabolites identified either alone or in combination appeared to be responsible for the observed effect. This study showed the iv aqueous fraction being the most active fraction followed by the methanol and then chloroform fraction. Key words: Analgesic activity, anti-inflammatory activity, solvent fractions, Moringa stenopetala
  • No Thumbnail Available
    Item
    Evaluation of the Analgesic and Anti-Inflammatory Activities Of 80% Methanol Leaf Extract of Stephania Abyssinica (Quart.-Dill. & A. Rich.) Walp. (Menispermaceae) in Mice
    (Addis Ababa University, 2015-05) Leyikun, Tigist; Engidawork, Ephrem (PhD); Nedi, Teshome (PhD)
    Stephania abyssinica is used in Ethiopian traditional medicine for the treatment of stomachache, headache and inflammation. The present study evaluated the 80% methanol leaf extract of S. abyssinica for its analgesic and anti-inflammatory activities. Dried leaves of the plant were extracted using maceration technique. Antinociceptive and antinflammatory activity were evaluated using hot plate test, acetic acid induced writhing test, formalin test and carrageenan induced paw edema test. Swiss albino mice of either sex were randomly assigned into five groups of six mice each. The extract reduced the number of writhing at all doses though to a lesser extent than aspirin. Increase in latency time was observed throughout the observation time. Greater increase in latency was observed at the 30 minute and lesser on the other time intervals. In the formalin test, 200 mg/kg and 400 mg/kg of the extract reduced paw-licking time more significantly in the second phase. During carrageenan-induced paw edema test, paw volume was considerably decreased in the second phase. The plant extract contained alkaloids, flavonoids, tannins and saponins. This study showed that the extract had potential analgesic and anti-inflammatory activity. Key words: Analgesic activity, Anti- inflammatory activity, Stephania abyssinica