Evaluation of Analgesic and Anti-Inflammatory Activities of Solvent Fractions of the Leaves of Moringa Stenopetala Bak.F. In Swiss Albino Mice

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Addis Ababa University


Many people still experience pain and inflammation regardless of the available drugs for treatments. In addition, the available drugs have many side effects, which necessitated a quest for new drugs from several sources with medicinal plants being one of them. This study evaluated the analgesic and anti- inflammatory activity of the solvent fractions of Moringa stenopetala. Successive soxhlet and maceration were used as methods of extractions and Chloroform, methanol and water were used as solvents. Radiant tail flick latency, acetic acid induced writhing and carrageenan induced paw edema models were used to assess the analgesic and anti-inflammatory activities. The test groups received different doses of the three fractions 100 mg/kg, 200 mg/kg and 400 mg/kg. The positive control groups received either Morphine 20 mg/kg or Aspirin at 100 mg/kg or 150 mg/kg. The control groups received the vehicles distilled water or 2% Tween80, 10 ml/kg. In all models the chloroform fraction had protections only at a dose of 400 mg/kg. But, the methanol and aqueous fraction at all doses have shown a significant central and peripheral analgesic and anti-inflammatory activity having comparable effects with standards. Phytochemical screening test revealed differential distribution of secondary metabolites amongst the fractions and the metabolites identified either alone or in combination appeared to be responsible for the observed effect. This study showed the iv aqueous fraction being the most active fraction followed by the methanol and then chloroform fraction. Key words: Analgesic activity, anti-inflammatory activity, solvent fractions, Moringa stenopetala



Analgesic activity, Anti-inflammatory activity, Solvent fractions, Moringa stenopetala