Pathology

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Browsing Pathology by Subject "Breast swelling"

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    Concordance of Breast Cytology based on the Yokohama Classification with Ultrasound ACR BIRADS Category in Women with Breast Swelling Examined at Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia
    (Addis Ababa University, 2025-01-29) Betelhem Gebreamlak; Amanuel Damie; Firdosa Ahmed
    Background: The fine needle aspiration cytology (FNAC) has been widely applied as part of the triple-test for breast cancer. The Yokohama system of classification of FNAC has been designed to boost the communications between clinicians and pathologists. Studying the concordance of FNAC based on the Yokohama classification with ultrasound breast imaging reporting and data system (BIRADS) categories is vital to promote the combined use of the two diagnostic systems. Objective: To investigate concordance of FNAC based on the Yokohama classification with the ultrasound ACR BIRADS category in women with breast swelling examined at Tikur Anbessa Specialized Hospital (TASH), Addis Ababa, Ethiopia. Method: Retrospective cross-sectional study was conducted from March 2024 to January 2025. A total of 116 women with breast swellings examined at Pathology and Radiology departments of TASH from January 1, 2022 to December 31, 2024, who had hospital records of both FNAC and ultrasound diagnostic results were included. Data were analyzed using STATA version 14. Descriptive statistics, Kappa weight and logistic regression analyses were used to describe the participants, assess concordance of the two systems and association of factors, respectively. Result: Among the total of 116 patients included in this study, the FNAC test results of 49, 5, 8 and 54 patients were classified as benign, atypical, suspicious for malignancy and malignant, respectively based on the Yokohama system of classification. Also, the ultrasound test results of 41, 8, 14 and 53 patients were classified as benign, probably benign, suspicious for malignancy and highly suggestive of malignancy, respectively based on BIRADS. The concordance of the test results based on the two systems was 81.90% regarding all the four categories in each of the two systems, 91.80% with respect to the last two categories in each of the two systems, while it was 88.80% with respect to three merged categories based on their risk of malignancy (ROM). Conclusion: The study revealed a high overall concordance of the breast lesion test results of FNAC based on the Yokohama system of classification with the ultrasound test results based on the ACR BIRADS categories. This shows that the integration of these two systems can foster the accuracy of the diagnostic approaches used for early detection of breast cancer cases.