Browsing by Author "Yoseph, Eshetu"

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    Prevalence of ARV-related Adverse Drug Reactions among Children Taking HAART at Hosanna Hospital
    (Addis Ababa University, 2013-06) Yoseph, Eshetu; Tadesse, Mekonnen (Ass. Prof.)
    In Ethiopia approximately 1.2 million people were living with HIVIAIDS in 2010. It is known that 134,586 children live with HIVIAIDS. Out of these, more than 67, 000 are estimated to be eligible for Anti Retroviral Treatment (ART) but only 4863 were taking HIVIAIDS Anti Retroviral Treatment by March 2008. Although Antiretroviral Treatment (ART) has decreased HIV-associated mortality and morbidity, a number of patients still die after the start of ART The objective of this study was to assess prevalence of some adverse drug reactions among HIVinfected children under ART The patients were those on ART follow-up at Hosanna H05pital. A sample of 1 05 patients has been collected among patients on ART !i'OII! May 2005 to April; 2013. The analysis of the data using the binOlY logistic regression showed that AZT-associated anemia, d4T-associated peripheral neuropathy and NVP-associated skin rash had influence on the survival of patients. i. e. Children HIV patients under ART follow up have developed AZT-associated anemia, d4T-associated peripheral neuropathy and NVP-associated skin rash. The results of the study indicated that adverse drug reaction has relation with age, baseline weight, baseline CD4 counts, WHO clinical stages and ART regimen Health workers should take into account the relationship between clinical parameters and that of complete blood group count, chemistry tests and enzyme tests to decide the overall situation for all HIVinfected patients under ART And the Drug Administration and Control Authority should strengthen the regular monitoring of ADRs especially those associated with ARVs.