Browsing by Author "Yizelkal, Selamawit"

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    Sociodemographic Features, Risk Factors, Clinical Characteristics and Treatment Outcomes of Patients with Chronic Portal Vein Thrombosis Seen at TASH and Adera Medical Center during the Period between August 2019 and August 2021, Addis Ababa, Ethiopia
    (Addis Abeba University, 2021-08) Yizelkal, Selamawit; Prof.Bane, Abate(MD,Consultant Internist and Gastroenterologist/hepatologist)
    Background:Portal vein thrombosis is the most common cause of extra-hepatic portal vein obstruction. Its prevalence is variable based on studied population, but is higher in developing countries than developed countries. PVT is mainly associated with cirrhosis and depends on the severity of the disease. Objectives: This study was conducted to assess the socio-demographic features, risk factors, clinical characteristics and treatment outcomes of patients with chronic portal vein thrombosis seen at Tikur Anbessa specialized hospital (TASH) and Adera medical center during the period between August 2019 and August 2021, Addis Ababa, Ethiopia. The study also tried to assess the difference of presentation and outcome of patients between cirrhotic andnoncirrhoticPortal vein thrombosis (PVT). Methods and materials: The study will be conducted as a cross sectional cohort descriptive study in two centers to describe the socio-demographic features risk factors, clinical characteristics and treatment outcome of PVT in patients following at Gastrointestinal (GI) outpatient clinic, or admitted at the emergency department (ED), intensive care unit (ICU) or medical wards in TASH and Adera medical center, Addis Ababa University. Datawas gathered through review of medical records and a questionnaire regarding their demographic characteristics, and clinical information including etiology, results of laboratory and imaging tests.The data was checked for clarity and completeness. Computerized data analysis was conducted by using SPSS (statistical package for the social sciences) version 26 software. Results:The mean age at diagnosis was 34.64 (± 11.86) years. Majority of patients in the study were male (52 (69.3%) Vs 23(30.7%)). Majority of patients (63.9%) had chronic presentation than acute presentation, which was seen in 36.1%. Majority of patients had normal liver enzymes and coagulation profile. The most common risk factors identified in this study were cirrhosis (28%), MPD (17.3%) and intra-abdominal infections (12%). The most common compilations identified were esophageal varices, portal hypertensive gastropathy, ascites and gastric varices. Endoscopic variceal band ligation was done, nonselective beta blocker, anticoagulation was given for 29, 38& 24 patients, respectively. Mortality among the 75 patients were 2.7%, 12 patients were lost to follow up and 61 patients continued follow up. Mortality was mainly as a result of the underling cirrhosis. Conclusion: Most Portal vein thrombosis patients in this study had chronic presentations of symptoms. Mortality of patients with cirrhosis is higher than those without cirrhosis.