Browsing by Author "Yhdego, Kidane"

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    Assessment of hematological and biochemical alteration in type II diabetes mellitus patients attending Aksum St. Marry Hospital, Aksum, Northern Ethiopia
    (Addis Abeba University, 2021-09) Yhdego, Kidane; Tamir, Zemenu (MSc, PHD candidate); Alemu, Rahel(BSc, MSc)
    Background: Diabetes mellitus is a non-communicable disease that has a high prevalence worldwide. Altered level of many hematological and biochemical parameters have been observed in patients with diabetes. Although type ӀӀ diabetes mellites alters hematological and biochemical parameters, so far, very little work has been done in Ethiopia linking hematological parameters and biochemical markers with type ӀӀ diabetes mellites patients. Objective: To assess alteration of hematological and biochemical parameters in type ӀӀ diabetes mellitus patients attending Aksum St. Marry Hospital, Aksum, Northern Ethiopia, from December 2019-April 2020 Method: comparative cross-sectional study was conducted from December 2019 to April 2020 at Aksum St. Marry Hospital, Aksum, Northern Ethiopia. A total of 168 participants were enrolled using convenient sampling method. Socio-demographic, behavioral and physical measurement data were collected. Complete blood count was performed by sysmex KX-21N hematology analyzer. The biochemical parameters were analyzed by using BE200. Data was analyzed using SPSS 23. Student independent t-test and person’s correlation statistical method employed to analyze data. P values < 0.05 was regarded as statistically significant at 95% confidence level. Result: Among the hematological parameters WBC count, neutrophil count, lymphocytes count, platelet count, MPV significantly increased. Similarly, RBC count, hemoglobin and PCV showed significant decrease in T2DM patients compared to controls. With regard to biochemical parameters ALT, AST, ALP, Creatinine and urea showed significantly increasing in T2DM patients when compared to controls. Regarding correlation, WBC with BMI and MCHC with FBS had positive correlations. Conclusion: There is alteration in total WBC, neutrophil, lymphocyte, eosinophil, basophil, RBC, hemoglobin and PCV. Also, from biochemical parameters ALT, AST, ALP, urea and creatinine altered in diabetes patients compared with control group.