Browsing by Author "Tesfaye Raji"

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    Assessment of Effect of Helicobacter Pylori and Helminths Infection on Anemia with Emphasis on Ferritin Level of School Children in Batu Town, Oromia Region, Ethiopia, 2019
    (Addis Abeba University, 2021-05) Tesfaye Raji; Tsegaye Aster ; Taye Bineyam
    Background: In infants and young children, severe chronic anemia may lead to delayed growthand long term effects on neurodevelopment and behaviour. The main causes of anemia are:dietary iron deficiency; infectious diseases, deficiencies of other key micronutrients or inheritedconditions that affect red blood cells (RBCs). Iron deficiency accounts for about 50% of all casesof anemia which results in iron deficiency anemia (IDA). According to the Demography HealthSurvey, the prevalence of anemia among Ethiopian children under the age of 15 is estimated tobe about 24%, classifying it as a moderate public health problem as identified by WHO. Objective: To investigate the effect of Helicobacter pylori and Helminths infection on anemiawith emphasis on ferritin level of school children in Batu town, Oromia Region, Ethiopia. Methods: A comparative study was conducted on 161 primary school children aged 4-14 years.Serum samples were collected for serum ferritin level measurement using Beckman Coulterchemistry analyzer. Secondary data on haemoglobin and RBC indices were extracted usingformat. SPSS version 21 was used to enter and analyze data. Statistical significance wasdetermined between the groups using an independent t-test and a non-parametric Mann-WhitneyU testwithPvaluelessthan0.05. Results: A total of 161 samples were analyzed in this study, with 77 (47.8%) of them beingmales. Of them, 109 (67.7%) were in the cases group, while 52 (32.3%) were negative for bothH. pylori and helminths. There was no statistically significant difference in serum ferritin levelsbetween H. pylori stool antigen positive or H. pylori antibody positive children compared withthe control groups, (P=0.787, P= 0.350) respectively. There was no significant effect on serumferritin as well as hemoglobin, RBC indices between helminths infection when compared with acontrol group. The serum ferritin level (P=0.286), hemoglobin concentration (P=0.563), MCV(P=0.646), MCH (P=0.485), and MCHC (P=0.975) all increased as a result. Conclusion and Recommendation: The presence of Helicobacter pylori or helminths has noeffect on serum ferritin levels or the development of iron deficiency. Cohort studies are recommended for establishing a cause and effect relationship between H.pylori infection or helminths infection and serum ferritin levels.