Browsing by Author "Tesfay Mheret"

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    Association of Helicobacter Pylori Infection with Atopy and Allergic Disorders in Ziway, Central Ethiopia
    (Addis Ababa University, 2017-05) Tesfay Mheret; Tsegaye Aster
    Background: Some epidemiological and experimental data point to the protective effect ofHelicobacter pylori infection against the development of many extra-gastric diseases,including gastroesophageal reflux disease and its associated outcomes, childhood asthma andallergy. There is scarcity of data concerning this in Ethiopia. Objective: To assess the association of Helicobacter pylori infection with atopy and allergicdisorders in Ziway, Central Ethiopia Methods and materials: Health facilities and school based cross sectional study wasconducted from October 2016 to January 2017, Ziway, Ethiopia. A total of 461 children wereenrolled in the study. Participant‟s socio-demographic and clinical information was collectedusing International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire. Skinprick test was done; blood and stool samples were collected from each participant.Automated WBC and manual eosinophil count were performed from EDTA blood while total serum IgE, H. Pylori stool antigen test and serum antibody test were determined using ELISAtechnique. Descriptive statistics were used to express the socio-demographic characteristicsof the participants. Binary logistic regression was computed to assess association betweenvariables using SPSS version 20 for windows. P < 0.05 were taken as statistically significant. Results: The overall prevalence of past and current H.pylori infection was 70.3% and 5.2%,respectively. The overall prevalence of any sensitization was 2.4%. Our result also did notshow the protective effect of the bacteria. There was no association between past H.pyloriinfection and atopic sensitization and allergic conditions (OR 1.58, 95% CI 0.44, 5.70(P=0.48) and OR 0.96, 95% CI 0.56, 1.62 (P=0.86), respectively) and the current infection ofH. pylori was not associated with allergic conditions with OR 1.81, 95% CI 0.53, 6.22(P=0.35). In this study the IgE levels were elevated in current H.pylori infected atopicparticipants. Conclusion: In this study we didn‟t find any significant association between past and currentH.pylori infection with atopy or allergic conditions. Further studies with high qualitylongitudinal cohort are needed to map every possible correlates of the infection. Keywords: Helicobacter pylori, Atopy, Allergy, IgE