Browsing by Author "Tamrat Abebe"

Now showing 1 - 3 of 3
  • No Thumbnail Available
    Item
    Evaluating Microbiota Signatures, Intrinsic Subtypes, PIK3CA Gene Mutations and Alternative Diagnostic Modalities Among Ethiopian Breast Cancer Patients
    (Addis Ababa University, 2024-06-13) Zelalem Desalegn; Tamrat Abebe
    Female breast cancer incidence has risen to unprecedented levels. It is a complex disease presented with distinct morphology, biological behaviors, clinical outcome and prognosis. Consequently, classification of breast cancer, understanding the molecular events including PIK3CA mutations and exploration of environmental factors including microbiota have a central role in understanding tumor biology. However, there is limited evidences in sub-Saharan Africa (SSA) context including Ethiopia; therefore, this study was conducted to generate evidence-based data to improving breast cancer care in Ethiopia. Additionally, considering the limited infrastructure for breast cancer diagnosis, we did method evaluation between PCR methods and immunohistochemistry to suggest alternative methods
  • No Thumbnail Available
    Item
    Molecular Characterization and Antimicrobial Resistance Profile of Diarrheagenic Escherichia Coli In Under-Five Children in Central Ethiopia
    (Addis Ababa University, 2024-06-13) Tizazu Zenebe; Tamrat Abebe
    Many children fail to reach their development milestones due to several infection-related health problems in developing countries. One major infection-related health problem in under-five children (UFC) is diarrhea with the highest mortality rate in sub- Saharan Africa including Ethiopia. Diarrheagenic Escherichia coli (DEC) is the major causes of diarrhea in UFC. Emergence of antimicrobial resistance (AMR) among DEC and other diarrheagenic bacterial strains including extended-spectrum ß-lactamase (ESBL) and carbapenemase producing E. coli strains are among the major threats to health globally. DEC pathotypes have emerged due to genomic plasticity of the E. coli and are associated with different life-threatening clinical diseases. The epidemiology of DEC and their AMR profile and the genetic background of DEC are not well characterized in Ethiopia. The present study aimed to determine molecular epidemiology and AMR profile of DEC and to provide some genetic insight of DEC pathotypes isolated from UFC from Central Ethiopia
  • No Thumbnail Available
    Item
    Molecular Characterization and Antimicrobial Susceptibility Profile of Bacterial Isolates From Patients with Surgical Site Infection in Ethiopia: A Multicentre Prospective Cross-Sectional Study
    (Addis Ababa University, 2024-06-19) Tamrat Abebe; Adane Mihret
    Globally, surgical site infections (SSI) are the most reported healthcare-associated infections. The most common pathogens associated with surgical wound infection are Gram-negative bacteria, and Staphylococcus aureus. Antibiotic resistance is increasing annually, and a major challenge in the management of SSI. Despite several reports on phenotypic examinations of bacterial isolates, there are few data on the molecular characterstics and antimicrobial resistance genes of bacteri isolated patients with SSI in Ethiopia. Objective: The aim of this study was to isolate and determine the antimicrobial susceptibility pattern; genes associated with drug resistance and identify risk factors associated with surgical site infection in Ethiopia