Browsing by Author "Tadesse Solomon"

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    Establishment of Hematological Reference Intervals for Apparently Healthy Adult Residents in Asella town, Southeast Ethiopia
    (Addis Abeba University, 2019-06) Tadesse Solomon; Tsegaye Aster; Alemu Jemal
    Background: About 70% of medical decisions made by physicians are based on the informationpresented by laboratory results. However, test results by themselves are valueless unless reportedwith the appropriate reference interval or medical decision limit. Currently, Ethiopia use referenceintervals adopted from textbooks that refer mainly to Caucasian subjects. The country havingheterogeneous population, there is a need to establish locally derived hematological referenceinterval that could be used in Asella town, Arsi zone, Ethiopia. Objective: To establish hematological reference intervals for apparently healthy adults in Asellatown, southeast, Ethiopia. Methods: A cross sectional study was conducted from January to March 2019 on apparentlyhealthy individuals in Asella town aged from 18-60 years. Predesigned and structuredquestionnaire was used for collection of data on socio-demographic characteristics and dietarypattern of the reference population. Systematic random sampling technique was used. About 3mlof EDTA whole blood was collected and analyzed using Sysmex KX 21N automated hematologyanalyzer which analyses 60 tests per hour. The data was entered and analyzed by appropriatestatistical software (Epi Info and SPSS) and interpreted using non-parametric methods, by whichcentral 95% of the measured values was included in the intervals. Result: a total of 494 participants were recruited and 424 participants were involved in this studywith the median age of 28 years. Except WBC (3.4 to 10.1 x109/L) which showed no significantdifference, other men and non-pregnant women reference intervals are: RBC (4.77 to 6.07 x10/L;4.18 to 5.29 x1012/L), HGB (14.7 to 18.1 gm/dL; 12.7 to 15.7gm/dL), HCT (42.1 to 51.3%; 37.1to 44.4%) and PLT (159 to 336 x109/L; 177 to 376 x109/L), respectively.Pregnant women’s WBC,RBC, HGB and PLT are (4.9 to 13.2 x109/L, 3.58 to 4.9 x1012/L, 11.0 to 14.6gm/dL and (138 to368 x109/L), respectively. Conclusion: most of the hematological RI of this study was significantly different from currentlyin use in Asella referral and teaching hospital laboratory. The difference was also observed instudies of other African countries as well as studies from different parts of Ethiopia.