Browsing by Author "Sorssa Solomon"

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    in Vitro Evaluation of the Activity of Some Ethiopian Traditional Medicinal Plant Crude Extracts against Plasmodium Falciparum
    (Addis Ababa University, 1992-06) Sorssa Solomon; Petros Beyene (Professor)
    The crude extracts of six Ethiopian medicinal plants used traditionally for the treatment of malaria were screened for their in vitro anti-malarial activity. Methanol, chloroform and ethanol extracts of the six species of plants, Croton m'::rostachyus Del. (Euphorbaceae): Calpurnia aurea (Alt.) Benth. (Fabaceae); Buddeleia polystachya Fresen. (Loganiaceae); Terminalia schimperiana Hochst. (Comberetaceae); Dodonaea angustifolia L.f (Sapindaceae) and Jasminum grandiflorum L. (Oleaceae), were tested for possible schizonticidal effects. Of the extracts screened, methanol extract of £.macrostachyus fruits and Q.angustifolia seeds; and chloroform extracts of £. aurea leaves and £.macrostachyus fruits had lCSO values of less than 10 ~g/ml showing a high anti-malarial activity. The ethanolic extracts of £.macrostachyus fruits, !.schimperiana leaves; methanol extracts of !.schimperiana leaves and £. aurea leaves, !l. grandiflorum root and bark; chloroform extracts of l!. polystachya leaves; Q. angustifolia seeds, !l.grandiflorum root and bark: and !. schimperiana leaves possessed low activity with lCSO values between 11-50 pg/ml. All other solvent extracts of the plants had no activity.