in Vitro Evaluation of the Activity of Some Ethiopian Traditional Medicinal Plant Crude Extracts against Plasmodium Falciparum
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Date
1992-06
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Addis Ababa University
Abstract
The crude extracts of six Ethiopian medicinal plants
used traditionally for the treatment of malaria were
screened for their in vitro anti-malarial activity.
Methanol, chloroform and ethanol extracts of the six
species of plants, Croton m'::rostachyus Del.
(Euphorbaceae): Calpurnia aurea (Alt.) Benth. (Fabaceae);
Buddeleia polystachya Fresen. (Loganiaceae); Terminalia
schimperiana Hochst. (Comberetaceae); Dodonaea angustifolia
L.f (Sapindaceae) and Jasminum grandiflorum L. (Oleaceae),
were tested for possible schizonticidal effects. Of the
extracts screened, methanol extract of £.macrostachyus
fruits and Q.angustifolia seeds; and chloroform extracts of
£. aurea leaves and £.macrostachyus fruits had lCSO values of
less than 10 ~g/ml showing a high anti-malarial activity.
The ethanolic extracts of £.macrostachyus fruits,
!.schimperiana leaves; methanol extracts of !.schimperiana
leaves and £. aurea leaves, !l. grandiflorum root and bark;
chloroform extracts of l!. polystachya leaves; Q. angustifolia
seeds, !l.grandiflorum root and bark: and !. schimperiana
leaves possessed low activity with lCSO values between 11-50
pg/ml. All other solvent extracts of the plants had no
activity.
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Biology