Browsing by Author "Nedu Adisu"

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    Establishing Reference Interval for Hematological Parameters for Apparently Healthy Adult Men and Pregnant Women in Arbaminch, South Ethiopia
    (Addis Abeba University, 2021-09) Nedu Adisu; Tsegaye Aster ; Alemu Jemal
    Background: Hematological reference intervals (RIs) are important in routine assessments for thediagnosis of blood disorders, infectious diseases, immune diseases, diseases progression and assessmentsof ant-retroviral treatments. However, most of Africans including Ethiopia use RIs which are adoptedfrom textbook, manufacturer of machines or Western countries while several factors are affecting theseparameters. Objective: To establish hematological reference intervals for apparently healthy adult men and pregnantwomen at Arbaminch, Southern, Ethiopia, 2020/21. Methods: A cross-sectional study design was applied from Nov 2020 to Sep 2021. A systematic sampling technique was used to recruit a total of 312 men and pregnant women aged 18 years and above.Individuals who are apparently healthy(fulfill the eligibility criteria) and are voluntary toparticipate in thestudy were included. A structured questionnaire was used to collect data about socio-demographic, healthstatus, drug usage, and nutritional habit of the participants after getting the ethical clearance. Thelaboratory specimens (blood, urine, stool) were collected according to standard operating procedures(SOPs) and the laboratory investigation was performed. Quality control material for hematological testswas used according to the SOPs. Age and sex specific 2.5th and 97.5threference interval was determinedusing the non-parametric method. Data were entered and analyzed using SPSS version 23.0 software. Results:- The median and 95% RI for RBC parameters were, 4.92(4.32-5.79)*10/L, 14.8(13.217.08)g/dl and 45.2(41.3-54.18)% for RBC, Hgb and Hct respectively for adult men and 4.39(3.565.16)*10 12/L, 13(9.3-15.9)g/dl and 41(32.6-46.2)% for RBC, Hgb and Hct, respectively for pregnantwomen. The median and 95% RI for WBC parameters and platelet count were 7.5(4.14-11.5)*102.2(1.2-5.21)*109 /L, 0.7(0.3-1.2)*109/L, 4.8(2.06-7.88)*109/L, and 227(152-353.3)*10/L WBC count,absolute lymphocyte, absolute mixed cell and absolute neutrophil and platelet count for adult men and7.5(4.55-12.4)*109/L, 2.2(1.2-3.9)*109/L, 0.7(0.3-1.2)*109/L, 4.9 (1.9-10.1)*10/L and 202(142362)*109/L WBC, Lymphocyte, Mixed cell, Granulocyte and platelet count for male and pregnantwomen, respectively. Conclusion:- The result from the current study identified that there is variation in most of the referenceinterval of hematological parameters especially red cell parameters with reference intervals conducted in other parts of the country, Africans as well as western countries.