Browsing by Author "Mulatu, Belete"

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    Risk Factors of Mortality among HIV/Tb Co-Infected Patients under Art: A Case Study in Change Health Center, Northwest Ethiopia
    (Addis Abeba university, 2013-09) Mulatu, Belete; Wencheko, Eshetu(Professer)
    HIV infection is a major risk factor for the development of tuberculosis (TB). Tuberculosis is a cause of significant morbidity and mortality in patients with AIDS. The objective of this study was to identify risk factors of mortality among HIV/TB co-infected patients in Chagni Health Center, Awi zone in Amhara Regional State, northwest Ethiopia. This is a retrospective study based on 510 cases of HIV-infected TB patients of age 15 years and above who received anti-TB treatment between September 1, 2010 and April 30, 2013 and were followed until July 31, 2013. The Kaplan-Meier method was used to estimate survival time and Cox’s regression model was employed to identify covariates that have statistical significant effects on the survival of HIV/TB co-infected patients. The descriptive analysis showed that out of 510 patients, 200 (39%) patients died during ART and anti-TB treatment period, of these 113 (56.5%) were females. 303 (59.4%) patients had ����4 ���������� ≤ 200 ����������/������, 272 (53.3%) patients were in the age group (15 − 30), 265 (52.2%) patients were under-weight (������ ≤ 18.5) and 234 (45.9%) patients started treatment on D4T-based drug regimens. The results of the multivariate PH Cox regression analysis showed that having cd4 count ≤ 200cels/mm3 at the start of ART, presence of extra-pulmonary TB, being bedridden and WHO stage IV were associated with higher risk of mortality. On the other hand, those patients who took AZT-based drug regimens and having normal-weight (18.5 kg/m2 < bmil < 25 kg/m2 ) experienced lower risk of mortality.