Browsing by Author "Melese, Endale"

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    Evaluation of the Anti Peptic Ulcer Activity of the Leaf Extract of Plantago Lanceolata in Rodents.
    (Addis Ababa University, 2010-02) Melese, Endale; Engidawork, Ephrem
    The lesion of peptic ulcer disease (PUD) is a disrflption in the mucosal layer of the stomach or duodenum. An ulcer is di stinguished from erosion by its penetration through the muscularis mucosa or the muscular coating of the gastric or duodenal wall. PUD results from the imbalance between defensive factors that protect the mucosa and offensive factors that disrupt this important barrier. There are several different types of modern drugs for the treatment of PUD though they are associated with clinically significant drug interactions, side effects, and relapse. Thus, there is a need to develop new drugs. for which natural products are potential candidates. Planlago lanceolala is used traditionally for the treatment of upper respiratory inflammation, urinary conditions. uterotonic. vascular disorders. wound, cough, ulcer etc. The present study was undertaken to evaluate the anti ulcer activity of the aqueous extract, and mucilage of P. lanceolala using different rodent models of PUD. Negative controls were given distilled water. Whilst positive controls received ranitidine in acetic acid induced chronic gastric ulcer, cysteamine Hel induced duodenal ulcer and pylorus ligation induced gastric ulcer models; misoprostol was used in indomethacin induced gastric ulcer. One group of animals received 200 mg/kg (for mice) and the other group received 400 mg/kg (for mice) of the aqueous extract in each model. In addition, one group of animals received 172 mg/kg of the mucilage in acetic acid induced chronic gastric ulcer model. The aqueous extract showed a better healing of ulcer than the mucilage in the acetic acid induced chronic gastric ulcer as evidenced by the higher percent reduction in ulcer index (77.9% vs 51.9%) and ulcer score Crable I). The aqueous extract was therefore, used for further evaluation. The effect of the aqueous extract at 400 mg/kg was more effective in healing and/ or protecting ulcer in virtually all models than 200 mg/kg. The extract at both 200 mg/kg and 400 mg/kg produced reduction in ulcer index (P<0.05 and P