Browsing by Author "Getahun, Mehabaw"

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    Synthesis and Characterization of some Metal Complexes of Schiff Bases Derived from Ninhydrin and Each of A, L- Serine and A, L- Alanine
    (Addis Ababa Universty, 2001-06) Getahun, Mehabaw; Retta, Negussie (Professor)
    Complexes of Mn(II), Fe(III), Co(III), Co(II), Ni(II) and Zn(II) with two different intermediate Sohiff bases, one derived from ninhydrin and serine (Indane-l ,3-dione- 2-imine-N-2-(3-hydroxy) propionate, IDIHP) and another derived from ninhydrin and alanine (Indane-l,3-dione-2-imine-N-2-propionate, IDIP) were successfully synthesized. All complexes were distinctly colored and were characterized by elemental analysis, molar conductance, infrared and electronic spectral studies. The ligand (Schiff base) was shown to behave as a monobasic tridentate ONO donor. The Mn(II), Fe(III) complexes of both Schiff bases and Co(II) complex of IDIHP were found to contain only one ligand molecule plus water and chloride(s) per metal ion, while all the others contain two ligand molecules per metal ion. An octahedral geometry is proposed for the metal complexes. > In light of the anti-microbial activity of ninhydrin, comparative anti-microbial study of the complexes was undertaken against two gram-negative bacteria Escherichia coli and Proteus mirabilis and one gram- positive bacteria Staphylococcus aureus. It was revealed that most of the complexes of both Schiff bases and particularly Mn(Il), Fe(III) and Co(II) complexes, have a much enhanced activity than ninhydrin against P. mirabilis and S. aureus. All complexes except Co(II) complex of IDIHP showed a reduced activity against E. Coli.