Synthesis and Characterization of some Metal Complexes of Schiff Bases Derived from Ninhydrin and Each of A, L- Serine and A, L- Alanine
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Date
2001-06
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Addis Ababa Universty
Abstract
Complexes of Mn(II), Fe(III), Co(III), Co(II), Ni(II) and Zn(II) with two different
intermediate Sohiff bases, one derived from ninhydrin and serine (Indane-l ,3-dione-
2-imine-N-2-(3-hydroxy) propionate, IDIHP) and another derived from ninhydrin and
alanine (Indane-l,3-dione-2-imine-N-2-propionate, IDIP) were successfully
synthesized. All complexes were distinctly colored and were characterized by
elemental analysis, molar conductance, infrared and electronic spectral studies. The
ligand (Schiff base) was shown to behave as a monobasic tridentate ONO donor. The
Mn(II), Fe(III) complexes of both Schiff bases and Co(II) complex of IDIHP were
found to contain only one ligand molecule plus water and chloride(s) per metal ion,
while all the others contain two ligand molecules per metal ion. An octahedral
geometry is proposed for the metal complexes.
> In light of the anti-microbial activity of ninhydrin, comparative anti-microbial study
of the complexes was undertaken against two gram-negative bacteria Escherichia coli
and Proteus mirabilis and one gram- positive bacteria Staphylococcus aureus. It was
revealed that most of the complexes of both Schiff bases and particularly Mn(Il),
Fe(III) and Co(II) complexes, have a much enhanced activity than ninhydrin against
P. mirabilis and S. aureus. All complexes except Co(II) complex of IDIHP showed a
reduced activity against E. Coli.
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Keywords
Derived from Ninhydrin and Serine