Browsing by Author "Geremew, Helen"

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    Evaluation of Analgesic and Anti -inflammatory Activity of Moringa stenopetala Bak.(Moringaceae) in Mice
    (Addis Ababa University, 2014-06) Geremew, Helen; Engidawork, Ephrem (PhD)
    Moringa stenopetala Bak F.is commonly used in folk medicine as a single drug remedy to treat various aliments like; hypertension, headache, stomach disorders, asthma, diabetes and malaria. However, the use of the herb for treatment of pain and inflammation has not been scientifically investigated. Thus, in this experiment 80% methanol crude extract of the leaves of M.stenopetala was evaluated for its analgesic and anti-inflammatory properties using established animal models. Swiss albino mice of either sex were randomly divided into five groups of six mice per group. The negative control group was orally given 0.5 ml of distilled water. The positive control received standard drug (morphine 10 mg//kg, Acetyl salicylic acid 81mg/kg, Indomethacin 25mg/kg).The rest of the groups were treated with 80 % methanol extract of M. Stenopetala at doses of 200, 400 and 600 mg/kg.Animals were then subjected to a battery of tests including hot plate, tail flick, acetic acid induced writhing, and carrageenan induced paw oedema tests. M. stenopetala extract showed a dose-dependent significant reduction of pain in analgesia models (p<0.001) with 600 mg/kg dose producing the highest reduction. The extract significantly reduced carrageenan induced inflammation in a dose independent manner, in which the highest reduction of inflammation was observed at 400mg/kg. The data collectively indicate that 80% methanol extract of M. Stenopetala leaves have potential analgesic and anti-inflammatory activities against stimuli in the tested animals and can be recommended for further studies. Key words: M. stenopetala, analgesic activity, anti- inflammatory activity