Evaluation of Analgesic and Anti -inflammatory Activity of Moringa stenopetala Bak.(Moringaceae) in Mice
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Date
2014-06
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Addis Ababa University
Abstract
Moringa stenopetala Bak F.is commonly used in folk medicine as a single drug
remedy to treat various aliments like; hypertension, headache, stomach disorders,
asthma, diabetes and malaria. However, the use of the herb for treatment of pain and
inflammation has not been scientifically investigated. Thus, in this experiment 80%
methanol crude extract of the leaves of M.stenopetala was evaluated for its analgesic
and anti-inflammatory properties using established animal models. Swiss albino mice
of either sex were randomly divided into five groups of six mice per group. The
negative control group was orally given 0.5 ml of distilled water. The positive control
received standard drug (morphine 10 mg//kg, Acetyl salicylic acid 81mg/kg,
Indomethacin 25mg/kg).The rest of the groups were treated with 80 % methanol
extract of M. Stenopetala at doses of 200, 400 and 600 mg/kg.Animals were then
subjected to a battery of tests including hot plate, tail flick, acetic acid induced
writhing, and carrageenan induced paw oedema tests. M. stenopetala extract showed a
dose-dependent significant reduction of pain in analgesia models (p<0.001) with 600
mg/kg dose producing the highest reduction. The extract significantly reduced
carrageenan induced inflammation in a dose independent manner, in which the
highest reduction of inflammation was observed at 400mg/kg. The data collectively
indicate that 80% methanol extract of M. Stenopetala leaves have potential analgesic
and anti-inflammatory activities against stimuli in the tested animals and can be
recommended for further studies.
Key words: M. stenopetala, analgesic activity, anti- inflammatory activity
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Keywords
M. stenopetala; Analgesic activity; Anti- inflammatory activity